Walking a tightrope: the complex balancing act of R-loops in genome stability
JR Brickner, JL Garzon, KA Cimprich - Molecular cell, 2022 - cell.com
Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
Detection of alternative DNA structures and its implications for human disease
G Matos-Rodrigues, JA Hisey, A Nussenzweig… - Molecular Cell, 2023 - cell.com
Around 3% of the genome consists of simple DNA repeats that are prone to forming
alternative (non-B) DNA structures, such as hairpins, cruciforms, triplexes (H-DNA), four …
alternative (non-B) DNA structures, such as hairpins, cruciforms, triplexes (H-DNA), four …
R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response
Abstract R-loops are RNA–DNA-hybrid-containing nucleic acids with important cellular
roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability …
roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability …
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer
The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein
implicated in cancer. However, its substrates in cells are not fully delineated. Here …
implicated in cancer. However, its substrates in cells are not fully delineated. Here …
R-loop-dependent promoter-proximal termination ensures genome stability
C Xu, C Li, J Chen, Y Xiong, Z Qiao, P Fan, C Li, S Ma… - Nature, 2023 - nature.com
The proper regulation of transcription is essential for maintaining genome integrity and
executing other downstream cellular functions,. Here we identify a stable association …
executing other downstream cellular functions,. Here we identify a stable association …
R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability
Transcription poses a threat to genomic stability through the formation of R-loops that can
obstruct progression of replication forks. R-loops are three-stranded nucleic acid structures …
obstruct progression of replication forks. R-loops are three-stranded nucleic acid structures …
Structures, functions and adaptations of the human LINE-1 ORF2 protein
ET Baldwin, T van Eeuwen, D Hoyos, A Zalevsky… - Nature, 2024 - nature.com
Abstract The LINE-1 (L1) retrotransposon is an ancient genetic parasite that has written
around one-third of the human genome through a 'copy and paste'mechanism catalysed by …
around one-third of the human genome through a 'copy and paste'mechanism catalysed by …
Structural basis of R-loop recognition by the S9. 6 monoclonal antibody
C Bou-Nader, A Bothra, DN Garboczi… - Nature …, 2022 - nature.com
R-loops are ubiquitous, dynamic nucleic-acid structures that play fundamental roles in DNA
replication and repair, chromatin and transcription regulation, as well as telomere …
replication and repair, chromatin and transcription regulation, as well as telomere …
Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells
FJ Groelly, RA Dagg, M Petropoulos, GG Rossetti… - Molecular Cell, 2022 - cell.com
Aberrant replication causes cells lacking BRCA2 to enter mitosis with under-replicated DNA,
which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here, we …
which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here, we …
TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures
Enzymes of the TET family are methylcytosine dioxygenases that undergo frequent
mutational or functional inactivation in human cancers. Recurrent loss-of-function mutations …
mutational or functional inactivation in human cancers. Recurrent loss-of-function mutations …