Given that the PI3K/AKT pathway has manifested its compelling influence on multiple
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …

Non coding RNAs (ncRNAs) have emerged as regulators of human carcinogenesis by
affecting the expression of key tumor suppressor genes and oncogenes. They are divided …

Autophagy is a conserved catabolic process involving the degradation and recycling of
damaged biomacromolecules or organelles through lysosomal-dependent pathways and …

Mutations underlie all cancers, and their identification and study are the foundation of cancer
biology. We describe what we believe to be a novel approach to mutagenesis and cancer …

Adhesion of acute lymphoblastic leukemia (ALL) cells to bone marrow stroma cells triggers
intracellular signals regulating cell-adhesion-mediated drug resistance (CAM-DR). Stromal …

Abstract The NOTCH1-MYC-CD44 axis integrates cell-intrinsic and extrinsic signaling to
ensure the persistence of leukemia-initiating cells (LICs) in T-cell acute lymphoblastic …

Long noncoding RNAs (lncRNAs) have been identified as potential prognostic tools and
therapeutic biomarkers for a variety of human cancers. However, the functional roles and …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood malignancy that arises
from the clonal expansion of transformed T-cell precursors. Although T-ALL prognosis has …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer that comprises
10–15% of pediatric and~ 25% of adult ALL cases. Although the curative rates have …

Notch is commonly activated in lymphoid malignancies through ligand-independent and
ligand-dependent mechanisms. In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) …