Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …

Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

Transcriptome engineering applications in living cells with RNA-targeting CRISPR effectors
depend on accurate prediction of on-target activity and off-target avoidance. Here we design …

Condensed states of proteins, including liquid-like membraneless organelles and solid-like
aggregates, contribute in fundamental ways to the organisation and function of the cell …

CTCF is crucial to the organization of mammalian genomes into loop structures. According
to recent studies, the transcription apparatus is compartmentalized and concentrated at …

Advances in imaging technologies have revealed that many bacteria possess organelles
with a proteomically defined lumen and a macromolecular boundary. Some are bound by a …

Syncytial skeletal muscle cells contain hundreds of nuclei in a shared cytoplasm. We
investigated nuclear heterogeneity and transcriptional dynamics in the uninjured and …

Expression of proteins inside cells is noisy, causing variability in protein concentration
among identical cells. A central problem in cellular control is how cells cope with this …

There has been increasing interest in complex coacervates for deriving and transporting
biomaterials. Complex coacervates are a dense, polyelectrolyte‐rich liquid that results from …

Highlights•Metabolomics enables rapid measurements at 10–100 times higher throughput
than proteomics.•The achievable throughput opens entirely new scientific and medical …