Actinomycetes: still a source of novel antibiotics
O Genilloud - Natural product reports, 2017 - pubs.rsc.org
Covering: 2006 to 2017 Actinomycetes have been, for decades, one of the most important
sources for the discovery of new antibiotics with an important number of drugs and analogs …
sources for the discovery of new antibiotics with an important number of drugs and analogs …
Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
Diversity and natural functions of antibiotics produced by beneficial and plant pathogenic bacteria
JM Raaijmakers, M Mazzola - Annual review of phytopathology, 2012 - annualreviews.org
Soil-and plant-associated environments harbor numerous bacteria that produce antibiotic
metabolites with specific or broad-spectrum activities against coexisting microorganisms …
metabolites with specific or broad-spectrum activities against coexisting microorganisms …
Secondary metabolism in the lichen symbiosis
MJ Calcott, DF Ackerley, A Knight… - Chemical Society …, 2018 - pubs.rsc.org
Lichens, which are defined by a core symbiosis between a mycobiont (fungal partner) and a
photobiont (photoautotrophic partner), are in fact complex assemblages of microorganisms …
photobiont (photoautotrophic partner), are in fact complex assemblages of microorganisms …
Dereplication strategies in natural product research: How many tools and methodologies behind the same concept?
J Hubert, JM Nuzillard, JH Renault - Phytochemistry Reviews, 2017 - Springer
The development of new drugs will certainly benefit from an ever improving knowledge of
the living beings chemistry. However, identification of drugable molecules within the …
the living beings chemistry. However, identification of drugable molecules within the …
Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era
HU Van Der Heul, BL Bilyk, KJ McDowall… - Natural product …, 2018 - pubs.rsc.org
Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …
Dereplication: racing to speed up the natural products discovery process
SP Gaudêncio, F Pereira - Natural product reports, 2015 - pubs.rsc.org
Covering: 1993–2014 (July) To alleviate the dereplication holdup, which is a major
bottleneck in natural products discovery, scientists have been conducting their research …
bottleneck in natural products discovery, scientists have been conducting their research …
[HTML][HTML] Concepts and methods to access novel antibiotics from actinomycetes
Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …
more than half a century. Exhibiting various bioactivities, they provide valuable approved …
Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?
BO Bachmann, SG Van Lanen… - Journal of industrial …, 2014 - academic.oup.com
Microbial genome mining is a rapidly developing approach to discover new and novel
secondary metabolites for drug discovery. Many advances have been made in the past …
secondary metabolites for drug discovery. Many advances have been made in the past …
Natural product drug discovery in the genomic era: realities, conjectures, misconceptions, and opportunities
RH Baltz - Journal of Industrial Microbiology and Biotechnology, 2019 - academic.oup.com
Natural product discovery from microorganisms provided important sources for antibiotics,
anti-cancer agents, immune-modulators, anthelminthic agents, and insecticides during a …
anti-cancer agents, immune-modulators, anthelminthic agents, and insecticides during a …