Calcinosis cutis is characterized by the deposition of insoluble calcium salts in the skin and
subcutaneous tissue. The syndrome is separated into five subtypes: dystrophic calcification …

Senescence is a cellular state which involves cell cycle arrest and a proinflammatory
phenotype, and it has traditionally been associated with cellular and organismal aging …

Adipose tissues collectively as an endocrine organ and energy storage are crucial for
systemic metabolic homeostasis. The major cell type in the adipose tissue, the adipocytes or …

Because calcinosis cutis is a rare syndrome, there is a notable lack of controlled clinical
trials on its treatment. The efficacy of calcinosis treatment has only been reported in single …

Four phosphinic peptide libraries with compounds having the general formula p-Br-Ph-(PO 2-
CH 2)-Xaa′-Yaa′-Zaa′-NH 2 have been prepared and screened against 10 matrix …

Objectives To assess the association of fluoroquinolone use with tendon ruptures compared
with no fluoroquinolone and that of the four most commonly prescribed non-fluoroquinolone …

The substrate of matrix metalloproteinase 11 (MMP11) remains unknown. We have recently
shown that MMP11 is a negative regulator of adipogenesis, able to reduce and even to …

This brief review focuses on the emerging role of matrix metalloproteinase 11 (MMP-11) in
cancer progression. It has recently been shown that MMP-11 is induced in adipose tissue by …

BMS-275291 is an po bioavailable, sulfhydryl-based matrix metalloproteinase (MMP)
inhibitor currently in clinical development for the treatment of cancer. This inhibitor was …

Several phosphinic pseudo-tripeptides of general formula R-XaaΨ (PO2-CH2) Xaa '-Yaa '-
NH2 were synthesized and evaluated for their in vitro activities to inhibit stromelysin-3 …