Mammalian target of rapamycin (m TOR) is a central regulator of growth and immunity of
host cells. It's involvement in cancer and tuberculosis is well documented but least explored …

Abstract Mitogen Activated Protein Kinase1 (MAPK1) of Leishmania donovani functions as
key regulators of various cellular activities, which seem to be imperative for parasite survival …

Abstract Adenosine 3', 5'‐cyclic monophosphate (cAMP) is a stress sensor molecule that
transduces the cellular signal when Leishmania donovani moves from insect vector to …

There is currently no effective vaccine against leishmaniasis because of the lack of sufficient
knowledge about the Ags that stimulate host-protective and long-lasting T cell–mediated …

Currently, there is no approved vaccine for visceral leishmaniasis (VL) caused by L.
donovani. The ability to manipulate Leishmania genome by eliminating or introducing genes …

Leishmania has a remarkable ability to proliferate under widely fluctuating levels of essential
nutrients, such as glucose. For this, the parasite is heavily dependent on its gluconeogenic …

Cutaneous leishmaniasis (CL) is a neglected public health problem in developing countries
including Iran. CL is caused by different species of Leishmania parasites and results in …

Fig. 1. A dendogram which shows that all species of Leishmania have evolved from four
subgenera; Viannia, Mundinia, Leishmania and Sauroleishmania. It was constructed by MP …

H 89 – PF-03084014 inhibitor Skip to content PF-03084014 inhibitor Conclusion PF-03084014
was well tolerated and demonstrated promising clinical benefit in patients with refractory …

Leishmaniasis is a tropical vector-borne infection caused by protozoan Leishmania
parasites which are transmitted by the bite of various species of infected female …