Structure and Function of Somatostatin and its Receptors in Endocrinology

B Zhang, L Xue, ZB Wu - Endocrine Reviews, 2025 - academic.oup.com
Somatostatin analogs, such as octreotide, lanreotide, and pasireotide, which function as
somatostatin receptor ligands (SRLs), are the main drugs used for the treatment of …

Combination treatments to enhance peptide receptor radionuclide therapy of neuroendocrine tumours

S Adant, GM Shah, JM Beauregard - European journal of nuclear medicine …, 2020 - Springer
The incidence of neuroendocrine tumours (NETs) is increasing, but curative therapeutic
options are limited because diagnosis is often delayed until the tumour has metastasized …

Progesterone receptor expression in granulosa cells is suppressed by microRNA-378-3p

D Toms, S Xu, B Pan, D Wu, J Li - Molecular and Cellular Endocrinology, 2015 - Elsevier
In developing ovarian follicles, the progesterone receptor (PGR) is essential for mediating
transcription of key factors that coordinate cellular functions including follicular remodeling …

Novel insights into the genetic basis of buffalo reproductive performance

J Li, J Liu, G Campanile, G Plastow, C Zhang, Z Wang… - BMC genomics, 2018 - Springer
Background Fertility is a complex trait that has a major impact on the development of the
buffalo industry. Genome-wide association study (GWAS) has increased the ability to detect …

[HTML][HTML] Knockdown of CREB1 promotes apoptosis and decreases estradiol synthesis in mouse granulosa cells

P Zhang, J Wang, H Lang, W Wang, X Liu, H Liu… - Biomedicine & …, 2018 - Elsevier
Cyclic AMP response element-binding protein 1 (CREB1), a member of the CREB family, is
known to be involved in follicular growth, ovulation, and ovarian disease. However, the …

Effect of melatonin on regulation of apoptosis and steroidogenesis in cultured buffalo granulosa cells

H Riaz, MR Yousuf, A Liang, GH Hua… - Animal Science …, 2019 - Wiley Online Library
This study was aimed to address melatonin receptor expression, mRNA level of
hypothalamus and hypophysis hormone receptors (Gn RHR, FSHR, and LHR) …

Knockdown of CEBPβ by RNAi in porcine granulosa cells resulted in S phase cell cycle arrest and decreased progesterone and estradiol synthesis

YH Zhen, L Wang, H Riaz, JB Wu, YF Yuan… - The Journal of Steroid …, 2014 - Elsevier
Cultured ovarian granulosa cells (GCs) are essential models to study molecular
mechanisms of gene regulation during folliculogenesis. CCAAT enhancer binding proteins β …

Knockdown of CREB3/Luman by shRNA in mouse granulosa cells results in decreased estradiol and progesterone synthesis and promotes cell proliferation

F Zhao, N Wang, Y Yi, P Lin, K Tang, A Wang, Y Jin - PLoS One, 2016 - journals.plos.org
Luman (also known as LZIP or CREB3) is a transcription factor and a member of the cAMP
responsive element-binding (CREB) family proteins. Although Luman has been detected in …

Regulatory roles of ephrinA5 and its novel signaling pathway in mouse primary granulosa cell apoptosis and proliferation

T Worku, K Wang, D Ayers, D Wu, Z Ur Rehman… - Cell Cycle, 2018 - Taylor & Francis
Recent findings suggest that ephrinA5 (Efna5) has a novel role in female mouse fertility, in
addition to its well-defined role as a neurogenesis factor. Nevertheless, its physiological …

Phospholipase C inhibits apoptosis of porcine primary granulosa cells cultured in vitro

H Chen, Y Yang, Y Wang, Y Li, Y He, J Duan… - Journal of Ovarian …, 2019 - Springer
Phospholipase C (PLC) can participate in cell proliferation, differentiation and aging.
However, whether it has a function in apoptosis in porcine primary granulosa cells is largely …