Calcium diffusion in the thin 100 nm layer located between the plasma membrane and
docked vesicles in the pre-synaptic terminal of neuronal cells mediates vesicular fusion and …

Synaptic communication relies on the fusion of synaptic vesicles with the plasma membrane,
which leads to neurotransmitter release. This exocytosis is triggered by brief and local …

SNARE proteins zipper to form complexes (SNAREpins) that power vesicle fusion with target
membranes in a variety of biological processes. A single SNAREpin takes about 1 s to fuse …

Synaptotagmin interaction with anionic lipid (phosphatidylserine/phosphatidylinositol)
containing membranes, both in the absence and presence of calcium ions (Ca2+), is critical …

Abstract Synapotagmin-1 (Syt1) interacts with both SNARE proteins and lipid membranes to
synchronize neurotransmitter release to calcium (Ca2+) influx. Here we report the cryo …

Regulated exocytosis, which underlies many intercellular signaling events, is a tightly
controlled process often triggered by calcium ion (s)(Ca2+). Despite considerable insight …

Synapses at dendritic branches exhibit specific properties for information processing.
However, how the synapses are orchestrated to dynamically modify their properties, thus …

All membrane fusion reactions proceed through an initial fusion pore, including calcium-
triggered release of neurotransmitters and hormones. Expansion of this small pore to …

Munc13‐1 is a large banana‐shaped soluble protein that is involved in the regulation of
synaptic vesicle docking and fusion. Recent studies suggest that multiple copies of Munc13 …

Abstract Synaptotagmin-1 (Syt-1) self-assembles into ring-like oligomers, and genetic and
biochemical evidence suggest that oligomerization is needed to clamp synaptic vesicles and …