Humans are exposed to an ever-increasing number of environmental toxicants, some of
which have gradually been elucidated to be important risk factors for metabolic diseases …

Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

Systems Toxicology is the integration of classical toxicology with quantitative analysis of
large networks of molecular and functional changes occurring across multiple levels of …

With the development of smart devices and cloud computing, more and more public health
data can be collected from various sources and can be analyzed in an unprecedented way …

Integrated approaches using different in vitro methods in combination with bioinformatics
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …

The pharmaceutical industry faces unsustainable program failure despite significant
increases in investment. Dwindling discovery pipelines, rapidly expanding R&D budgets …

Nowadays, nanomaterials (NMs) are widely present in daily life due to their significant
benefits, as demonstrated by their application in many fields such as biomedicine …

Metabolomics is a widely used technology in academic research, yet its application to
regulatory science has been limited. The most commonly cited barrier to its translation is …

Liver toxicity is a leading systemic toxicity of drugs and chemicals demanding more human-
relevant, high throughput, cost effective in vitro solutions. In addition to contributing to animal …

The first guidance on Good Cell Culture Practice dates back to 2005. This document
expands this to aspects of quality assurance for in vitro cell culture focusing on the …