Babesiosis is an emerging tick-borne disease caused by apicomplexan parasites of the
genus Babesia. With its increasing incidence worldwide and the risk of human-to-human …

Absence of an effective high-throughput drug-screening system for Babesia parasites is
considered one of the main causes for the presence of a wide gap in the treatment of animal …

Although a group of FDA-approved drugs were previously identified with activity against
Ebola virus (EBOV), most of them are not clinically useful because their human blood …

Twenty-five patients with relapsing and remitting Borreliosis, Babesiosis, and bartonellosis
despite extended anti-infective therapy were prescribed double-dose dapsone combination …

Abstract Background The apicomplexan hemoparasite Theileria equi is a causative agent of
equine piroplasmosis, eradicated from the United States in 1988. However, recent outbreaks …

Cryptosporidiosis is an imperative global health concern. Unfortunately, Nitazoxanide
(NTZ)(the nowadays drug of choice) is not effective in treatment of immunocompromised …

Toxoplasmosis is a disease with a worldwide distribution and significant morbidity and
mortality. In search of effective treatment, mefloquine (MQ) was repurposed and loaded with …

Plasmepsin IX and X, members of the prominent aspartic family of proteases whose function
were hitherto unknown have only recently been established as key mediators of erythrocyte …

B. caballi were observed with IC50 values of 80, 70, 57, and 65 nM, respectively. Their
development was remarkably inhibited at observed concentrations of 10, 25, 50, and 100 …

Inhibition of aspartic cathepsin D-like peptidases (APDs) has been often discussed as an
antiparasite intervention strategy. APDs have been considered as virulence factors of …