From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal
organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical …

Systemic sclerosis (SSc) is a multisystem autoimmune and vascular disease resulting in
fibrosis of various organs with unknown etiology. Accumulating evidence suggests that a …

Microbial contributions to the immunopathogenesis of autoimmune rheumatic diseases have
been studied since the advent of germ theory in the 19th century. With the exception of …

During the last decades, high-throughput assessment of gene expression in patient tissues
using microarray technology or RNA-Seq took center stage in clinical research. Insights into …

Background Tissue fibrosis is a common pathway to failure in many organ systems and is
the cellular and molecular driver of myriad chronic diseases that are incompletely …

Abstract Purpose of Review Macrophages play key roles in tissue homeostasis and immune
surveillance, mobilizing immune activation in response to microbial invasion and promoting …

Objectives We characterized the microbiota in SSc, focusing on the skin–oral–gut axis and
the serum and faecal free fatty acid (FFA) profile. Methods Twenty-five SSc patients with …

The microbial community acts as an active player in maintaining homeostasis and immune
functions through a continuous and changeable cross-talk with the host immune system …

Importance Systemic sclerosis (SSc) is a severe, chronic, and incurable autoimmune fibrotic
skin disease with significant extracutaneous involvement. Low concordance rate in twin …

Systemic sclerosis (SSc), also known as scleroderma, is an autoimmune disease with
unknown etiology characterized by multi-organ fibrosis. Despite substantial investigation on …