Naturally occurring food-derived active ingredients have received huge attention for their
chemopreventive and chemotherapy capabilities in several diseases. Rosmarinic acid (RA) …

Background Reactive oxygen and nitrogen species, known as free radicals, play a key role
in the etiology and progression of atherosclerotic cardiovascular disease by creating …

Significance: Endothelial cells lining the lumen of blood vessels play an important role in the
regulation of cardiovascular functions through releasing both vasoconstricting and …

Pre-conditioning by ischemia, hyperthermia, hypothermia, hyperbaric oxygen (and
numerous other modalities) is a rapidly growing area of investigation that is used in …

Acute kidney injury (AKI) is the most common condition in hospitalized patients. As
ischemia/reperfusion-induced AKI (IR-AKI) is as a major contributor to end-stage disease, an …

Objective: To investigate the potential protective effects of Rosmarinic acid (RA) on rats
exposed to ischaemia/reperfusion renal injury. Methods: The prospective study was …

Protein oxidative or redox modifications induced by reactive oxygen species (ROS) or
reactive nitrogen species (RNS) not only can impair protein function, but also can regulate …

Mitochondrial dysfunction plays a pivotal role in necroapoptotic cell death and in the
development of acute kidney injury (AKI). Evidence suggests that glycogen synthase kinase …

The anti-aging strategy is one of the main challenges of the modern biomedical science. The
term “aging” covers organisms, cells, cellular organelles and their constituents. In general …

Ischemia-reperfusion injury is the leading cause of acute kidney injury in a variety of clinical
settings such as renal transplantation and hypovolemic and/or septic shock. Strategies to …