Niemann-Pick type C (NPC) disease is a lysosomal storage disease in which endocytosed
cholesterol becomes sequestered in late endosomes/lysosomes (LEs/Ls) because of …

All animal subcellular membranes require cholesterol, which influences membrane fluidity
and permeability, fission and fusion processes, and membrane protein function. The …

Viruses communicate with their hosts through interactions with proteins, lipids, and
carbohydrate moieties on the plasma membrane (PM), often resulting in viral absorption via …

Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

Lysosomal storage disorders (LSDs) are rare inherited debilitating and often fatal disorders.
Caused by mutations affecting lysosomal proteins, LSDs are characterized by the …

Mammalian cells acquire most exogenous cholesterol through receptor‐mediated
endocytosis of low‐density lipoproteins (LDLs). After internalization, LDL cholesteryl esters …

Mitochondria require cholesterol for biogenesis and membrane maintenance, and for the
synthesis of steroids, oxysterols and hepatic bile acids. Multiple pathways mediate the …

Cholesterol is an essential component of mammalian cell membranes and a precursor for
crucial signaling molecules. The brain contains the highest level of cholesterol in the body …

Acetyl-dl-leucine is a derivative of the branched chain amino acid leucine. In observational
clinical studies, acetyl-dl-leucine improved symptoms of ataxia, in particular in patients with …

The intracellular cholesterol transporter NPC1 functions in late endosomes and lysosomes
to efflux unesterified cholesterol, and its deficiency causes Niemann–Pick disease Type C …