Pharmacological management of binge eating disorder: current and emerging treatment options
SL McElroy, AI Guerdjikova, N Mori… - … and Clinical Risk …, 2012 - Taylor & Francis
Growing evidence suggests that pharmacotherapy may be beneficial for some patients with
binge eating disorder (BED), an eating disorder characterized by repetitive episodes of …
binge eating disorder (BED), an eating disorder characterized by repetitive episodes of …
Melanin-concentrating hormone: a new sleep factor?
P Torterolo, P Lagos, JM Monti - Frontiers in neurology, 2011 - frontiersin.org
Neurons containing the neuropeptide melanin-concentrating hormone (MCH) are mainly
located in the lateral hypothalamus and the incerto-hypothalamic area, and have …
located in the lateral hypothalamus and the incerto-hypothalamic area, and have …
Recent advance in the pharmacology of dihydropyrimidinone
JP Wan, Y Pan - Mini Reviews in Medicinal Chemistry, 2012 - ingentaconnect.com
Dihydropyrimidinones (DHPMs) are a series of highly valuable small molecules possessing
versatile pharmaceutical properties. Although the first one-pot synthesis of DHPMs had been …
versatile pharmaceutical properties. Although the first one-pot synthesis of DHPMs had been …
Discovery of (3-(4-(2-oxa-6-azaspiro [3.3] heptan-6-ylmethyl) phenoxy) azetidin-1-yl)(5-(4-methoxyphenyl)-1, 3, 4-oxadiazol-2-yl) methanone (AZD1979), a melanin …
A Johansson, C Lofberg, M Antonsson… - Journal of Medicinal …, 2016 - ACS Publications
A novel series of melanin concentrating hormone receptor 1 (MCHr1) antagonists were the
starting point for a drug discovery program that culminated in the discovery of 103 …
starting point for a drug discovery program that culminated in the discovery of 103 …
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists
S Sasmal, G Balaji, HRK Reddy… - Bioorganic & medicinal …, 2012 - Elsevier
Melanin concentrating hormone (MCH) is an important mediator of energy homeostasis and
plays a role in metabolic and CNS disorders. The modeling-supported design, synthesis and …
plays a role in metabolic and CNS disorders. The modeling-supported design, synthesis and …
WDL-RF: predicting bioactivities of ligand molecules acting with G protein-coupled receptors by combining weighted deep learning and random forest
Motivation Precise assessment of ligand bioactivities (including IC50, EC50, Ki, Kd, etc.) is
essential for virtual screening and lead compound identification. However, not all ligands …
essential for virtual screening and lead compound identification. However, not all ligands …
Depressive-like profile induced by MCH microinjections into the dorsal raphe nucleus evaluated in the forced swim test
P Lagos, J Urbanavicius, MC Scorza… - Behavioural brain …, 2011 - Elsevier
Antagonism of the melanin-concentrating hormone (MCH) receptor 1 (MCH-R1) has been
recently shown to have antidepressant-like profile in rats. However, the mechanisms by …
recently shown to have antidepressant-like profile in rats. However, the mechanisms by …
Alpha-melanocyte-stimulating hormone-mediated appetite regulation in the central nervous system
Q Wu, J Chen, T Hua, J Cai - Neuroendocrinology, 2023 - karger.com
Understanding the complex action mechanism of appetite regulation peptides can
significantly impact therapeutic options in the treatment of obesity and other metabolic …
significantly impact therapeutic options in the treatment of obesity and other metabolic …
Immunoneutralization of melanin-concentrating hormone (MCH) in the dorsal raphe nucleus: effects on sleep and wakefulness
P Lagos, P Torterolo, H Jantos, JM Monti - Brain research, 2011 - Elsevier
Hypothalamic neurons that utilize melanin-concentrating hormone (MCH) as a
neuromodulator exert a positive control over energy homeostasis, inducing feeding and …
neuromodulator exert a positive control over energy homeostasis, inducing feeding and …
Precise modelling and interpretation of bioactivities of ligands targeting G protein-coupled receptors
Motivation Accurate prediction and interpretation of ligand bioactivities are essential for
virtual screening and drug discovery. Unfortunately, many important drug targets lack …
virtual screening and drug discovery. Unfortunately, many important drug targets lack …