Phosphorylation is an essential process in biological events and is considered critical for
biological functions. In tissues, protein phosphorylation mainly occurs on tyrosine (Tyr) …

Abstract Thiazolidinediones (TZDs) or Glitazones are an important class of insulin
sensitizers used in the treatment of Type 2 diabetes mellitus (T2DM). TZDs were reported for …

This report describes a number of substructural features which can help to identify
compounds that appear as frequent hitters (promiscuous compounds) in many biochemical …

Abstract Hydantoin, imidazolidine-2, 4-dione, is a non-aromatic five-membered heterocycle,
which is considered a valuable, privileged scaffold in medicinal chemistry. The importance …

Diabetes Mellitus (DM) is the fastest growing metabolic disorder affecting about 387 million
people across the globe and is estimated to affect 592 million people by year 2030. The …

The presented review is an attempt to summarize a huge volume of data on 5-ene-4-
thiazolidinones being a widely studied class of small molecules used in modern organic and …

Rhodanines, thiazolidine-2, 4-diones and pseudothiohydantoins have become a very
interesting class of heterocyclic compounds since the introduction of various glitazones and …

Introduction: Protein tyrosine phosphatase 1B (PTP1B) plays an important role in the
negative regulation of insulin signal transduction pathway and has emerged as novel …

Thiazolidinedione is an important heterocyclic ring system, a pharmacophore and a
privileged scaffold in medicinal chemistry; is a derivative of thiazolidine ring which came into …

Type 2 diabetes mellitus (T2D) is a metabolic disorder that knows no boundaries and is
spread across the globe. It is one of the most widely spread metabolic disorder, which has …