Formation of skeletal muscle fibers (myogenesis) during development and after tissue injury
in the adult constitutes an excellent paradigm to investigate the mechanisms whereby …

Fibroblast growth factors (FGFs) are essential for self‐renewal of skeletal muscle stem cells
(satellite cells) and required for maintenance and repair of skeletal muscle. Satellite cells …

Abstract p38 MAPKs play a central role in orchestrating the cellular response to stress and
inflammation and in the regulation of myogenesis. Potent inhibitors of p38 MAPKs have …

Duchenne muscular dystrophy (DMD) is a multisystemic disorder that affects 1: 5000 boys.
The severity of the phenotype varies dependent on the mutation site in the DMD gene and …

Adult stem cells sustain tissue homeostasis and regeneration; their functional decline is
often linked to aging, which is characterized by the progressive loss of physiological …

Facioscapulohumeral muscular dystrophy (FSHD) is characterized by misexpression of the
double homeobox 4 (DUX4) developmental transcription factor in mature skeletal muscle …

Krüppel-like factor 5 (Klf5) is a zinc-finger transcription factor that controls various biological
processes, including cell proliferation and differentiation. We show that Klf5 is also an …

The discovery of the skeletal muscle-specific transcription factor MyoD represents a
milestone in the field of transcriptional regulation during differentiation and cell-fate …

Since its discovery as a skeletal muscle-specific transcription factor able to reprogram
somatic cells into differentiated myofibers, MyoD has provided an instructive model to …

The ability of myofibers to sense and respond appropriately to mechanical signals is one of
the primary determinants of the skeletal muscle phenotype. In response to a change in …