Systemic lupus erythematosus (SLE) is a complex and heterogeneous systemic
autoimmune disease associated with innate and adaptive immune dysregulation. SLE …

Cytokine release syndrome (CRS) embodies a mixture of clinical manifestations, including
elevated circulating cytokine levels, acute systemic inflammatory symptoms and secondary …

Lupus nephritis (LN) is a major cause of morbidity and mortality among patients with
systemic lupus erythematosus (SLE). However, promising emerging biomarkers pave the …

Chemokines are a group of cytokines with low molecular weight that principally direct
chemotaxis of target cells. They have prominent roles in the pathogenesis systemic lupus …

Objective Dysregulation of transfer RNA (tRNA)-derived small noncoding RNA (tsRNA)
signatures in human serum has been found in various diseases. Here, we determine …

NGAL holds promise as a versatile biomarker in SLE whereas urine ALCAM, CD163 and
VCAM-1 displayed good performance as biomarkers in LN. The overall lack of concerted …

Objectives Type I interferons (IFNs) are central and reflective of disease activity in systemic
lupus erythematosus (SLE). However, IFN-α levels are notoriously difficult to measure and …

Systemic lupus erythematosus is a debilitating autoimmune disease characterized by
uncontrolled activation of adaptive immunity, particularly B cells, which predominantly affects …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with heterogeneous
clinical manifestations and the pathogenesis of SLE is still unclear. Various omics results …

Background Autoreactive B cells are well recognized as key participants in the pathogenesis
of systemic lupus erythematosus (SLE). However, elucidating the particular subset of B cells …