Systemic inflammation can be triggered by infection, surgery, trauma or burns. During
systemic inflammation, an overshooting immune response induces tissue damage resulting …

Over the last years, there have been advances in the use of data-driven techniques to
improve the definition, early recognition, subtypes characterisation, prognostication and …

A biomarker is a molecule that can be measured in a biological sample in an objective,
systematic, and precise way, whose levels indicate whether a process is normal or …

Purpose Investigate safety and tolerability of adrecizumab, a humanized monoclonal
adrenomedullin antibody, in septic shock patients with high adrenomedullin. Methods Phase …

Sepsis is a dysregulated systemic reaction to a common infection, that can cause life-
threatening organ dysfunction. Over the last decade, the mortality rate of patients with sepsis …

Numerous clinical studies have revealed the utility of circulating AM (adrenomedullin) or MR-
proAM (mid-regional proAM 45-92) as an effective prognostic and diagnostic biomarker for a …

Background Activation of the triggering receptor expressed on myeloid cells-1 (TREM-1)
pathway is associated with septic shock outcomes. Data suggest that modulation of this …

Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
collapsed health systems worldwide. In adults, the virus causes severe acute respiratory …

Sepsis is a major health problem worldwide. It is a time-dependent disease, with a high rate
of morbidity and mortality. In this sense, an early diagnosis is essential to reduce these rates …

Abstract Background Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in the
degradation of various cardiovascular and endorphin mediators. High levels of circulating …