The accumulation of a large number of myofibroblasts is responsible for exaggerated and
uncontrolled production of extracellular matrix during the development and progression of …

Fibrotic diseases encompass a wide spectrum of clinical entities including systemic fibrotic
diseases such as systemic sclerosis, sclerodermatous graft versus host disease …

Importance Risk of nephrogenic systemic fibrosis (NSF) to individual patients with stage 4 or
5 chronic kidney disease (CKD; defined as estimated glomerular filtration rate of< 30 …

Gadolinium-based contrast agents (GBCAs) have an excellent safety profile. However, over
the last 2 decades, two specific concerns have surfaced. GBCAs are associated with …

Nephrogenic systemic fibrosis is a new, rare disease of unknown cause that affects patients
with renal failure. Single cases led to the suspicion of a causative role of gadodiamide that is …

Scleroderma refers to an autoimmune connective tissue fibrosing disease, including three
different subsets: localized scleroderma, limited cutaneous systemic sclerosis, and diffuse …

Purpose of review: Use of gadolinium-based contrast agents (GBCA) in renal impairment is
controversial, with physician and patient apprehension in acute kidney injury (AKI), chronic …

Purpose: To retrospectively review data in 13 patients with biopsy-confirmed nephrogenic
systemic fibrosis (NSF), assess the associated risk factors, and report the incidence of NSF …

Gadolinium-based contrast agents (GBCAs) have transformed magnetic resonance imaging
(MRI) by facilitating the use of contrast-enhanced MRI to allow vital clinical diagnosis in a …

More frequently hospital clinicians are reviewing images from MR studies of their patients
before seeking formal radiological opinion. This practice is driven by a multitude of factors …