[HTML][HTML] Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

S Qin, W Xiao, C Zhou, Q Pu, X Deng, L Lan… - Signal transduction and …, 2022 - nature.com
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …

The type III secretion system of Pseudomonas aeruginosa: infection by injection

AR Hauser - Nature Reviews Microbiology, 2009 - nature.com
Abstract The Gram-negative bacterium Pseudomonas aeruginosa uses a complex type III
secretion apparatus to inject effector proteins into host cells. The configuration of this …

Protein export according to schedule: architecture, assembly, and regulation of type III secretion systems from plant-and animal-pathogenic bacteria

D Büttner - Microbiology and Molecular Biology Reviews, 2012 - Am Soc Microbiol
Flagellar and translocation-associated type III secretion (T3S) systems are present in most
Gram-negative plant-and animal-pathogenic bacteria and are often essential for bacterial …

Type III secretion systems: the bacterial flagellum and the injectisome

A Diepold, JP Armitage - Philosophical Transactions of …, 2015 - royalsocietypublishing.org
The flagellum and the injectisome are two of the most complex and fascinating bacterial
nanomachines. At their core, they share a type III secretion system (T3SS), a transmembrane …

Two-component systems required for virulence in Pseudomonas aeruginosa

VI Francis, EC Stevenson, SL Porter - FEMS microbiology letters, 2017 - academic.oup.com
Pseudomonas aeruginosa is a versatile opportunistic pathogen capable of infecting a broad
range of hosts, in addition to thriving in a broad range of environmental conditions outside of …

Protein secretion systems in Pseudomonas aeruginosa: a wealth of pathogenic weapons

S Bleves, V Viarre, R Salacha, GPF Michel… - International Journal of …, 2010 - Elsevier
Pathogenic microorganisms have to face hostile environments while colonizing and
infecting their hosts. Unfortunately, they can cope with it and have evolved a number of …

Gac/Rsm signal transduction pathway of γ‐proteobacteria: from RNA recognition to regulation of social behaviour

K Lapouge, M Schubert, FHT Allain… - Molecular …, 2008 - Wiley Online Library
In many γ‐proteobacteria, the conserved GacS/GacA (BarA/UvrY) two‐component system
positively controls the expression of one to five genes specifying small RNAs (sRNAs) that …

A multifunctional bispecific antibody protects against Pseudomonas aeruginosa

A DiGiandomenico, AE Keller, C Gao… - Science translational …, 2014 - science.org
Widespread drug resistance due to empiric use of broad-spectrum antibiotics has stimulated
development of bacteria-specific strategies for prophylaxis and therapy based on modern …

Regulation of virulence and antibiotic resistance by two-component regulatory systems in Pseudomonas aeruginosa

WJ Gooderham, REW Hancock - FEMS microbiology reviews, 2009 - academic.oup.com
The Gram-negative opportunistic pathogen Pseudomonas aeruginosa ubiquitously inhabits
soil and water habitats and also causes serious, often antibiotic resistant, infections in …

Plate-Based Assay for Swimming Motility in Pseudomonas aeruginosa

DG Ha, SL Kuchma, GA O'Toole - Pseudomonas methods and protocols, 2014 - Springer
Swimming motility is a flagellum-dependent form of movement observed in the Gram-
negative bacterium Pseudomonas aeruginosa. Swimming motility is defined as the …