Cell cultures are very important for testing materials and drugs, and in the examination of
cell biology and special cell mechanisms. The most popular models of cell culture are two …

Multicellular spheroids and organoids are promising in vitro 3D models in personalized
medicine and drug screening. They replicate the structural and functional characteristics of …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Cancer is a multifaceted pathology, where cellular and acellular players interact to drive
cancer progression and, in the worst-case, metastasis. The current methods to investigate …

Simple Summary For the research and development of drug discovery, it is of prime
importance to construct the three-dimensional (3D) tissue models in vitro. To this end, the …

The mechanisms behind cancer initiation and progression are not clear. Therefore,
development of clinically relevant models to study cancer biology and drug response in …

The tumour microenvironment (TME) shapes disease progression and influences
therapeutic response. Most aggressive solid tumours have high levels of myeloid cell …

Abstract Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three
dimensional (3D) architecture and complexity of human tumors. More representative models …

This review aims to show case recent regenerative medicine based on biomaterial
technologies. Regenerative medicine has arousing substantial interest throughout the world …

Three-dimensional multicellular tumor models are receiving an ever-growing focus as
preclinical drug-screening platforms due to their potential to recapitulate major physiological …