A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

H Kadry, B Noorani, L Cucullo - Fluids and Barriers of the CNS, 2020 - Springer
The blood–brain barrier is playing a critical role in controlling the influx and efflux of
biological substances essential for the brain's metabolic activity as well as neuronal function …

Reviewing the significance of blood–brain barrier disruption in multiple sclerosis pathology and treatment

R Balasa, L Barcutean, O Mosora, D Manu - International journal of …, 2021 - mdpi.com
The disruption of blood–brain barrier (BBB) for multiple sclerosis (MS) pathogenesis has a
double effect: early on during the onset of the immune attack and later for the CNS self …

Role of the blood–brain barrier in multiple sclerosis

GG Ortiz, FP Pacheco-Moisés, MÁ Macías-Islas… - Archives of medical …, 2014 - Elsevier
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system associated
with demyelination and axonal loss eventually leading to neurodegeneration. MS exhibits …

The role of environmental exposures in neurodegeneration and neurodegenerative diseases

JR Cannon, JT Greenamyre - Toxicological Sciences, 2011 - academic.oup.com
Neurodegeneration describes the loss of neuronal structure and function. Numerous
neurodegenerative diseases are associated with neurodegeneration. Many are rare and …

Immunology and oxidative stress in multiple sclerosis: clinical and basic approach

GG Ortiz, FP Pacheco-Moisés… - Journal of …, 2013 - Wiley Online Library
Multiple sclerosis (MS) exhibits many of the hallmarks of an inflammatory autoimmune
disorder including breakdown of the blood‐brain barrier (BBB), the recruitment of …

The role of thyroid hormones as inductors of oxidative stress and neurodegeneration

I Villanueva, C Alva-Sánchez… - … medicine and cellular …, 2013 - Wiley Online Library
Reactive oxygen species (ROS) are oxidizing agents amply implicated in tissue damage.
ROS production is inevitably linked to ATP synthesis in most cells, and the rate of production …

Efficacy of melatonin on serum pro-inflammatory cytokines and oxidative stress markers in relapsing remitting multiple sclerosis

AL Sánchez-López, GG Ortiz… - Archives of medical …, 2018 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory disease, which leads to focal plaques of
demyelination and tissue injury in the central nervous system (CNS). Neuroinflammation …

Efficacy of Fish Oil on Serum of TNFα, IL‐1β, and IL‐6 Oxidative Stress Markers in Multiple Sclerosis Treated with Interferon Beta‐1b

V Ramirez-Ramirez, MA Macias-Islas… - Oxidative medicine …, 2013 - Wiley Online Library
Multiple sclerosis (MS) is a chronic inflammatory disease, which leads to focal plaques of
demyelination and tissue injury in the central nervous system. Oxidative stress is also …

Albumin and multiple sclerosis

SM LeVine - BMC neurology, 2016 - Springer
Leakage of the blood–brain barrier (BBB) is a common pathological feature in multiple
sclerosis (MS). Following a breach of the BBB, albumin, the most abundant protein in …

Exploring the relationship between antioxidant enzymes, oxidative stress markers, and clinical profile in relapsing–remitting multiple sclerosis

A Bizoń, J Chojdak-Łukasiewicz, S Budrewicz… - Antioxidants, 2023 - mdpi.com
We aimed to investigate the extent of alterations in the pro/antioxidant balance in the blood
of patients with relapsing–remitting multiple sclerosis (RRMS) in relation to drug-modified …