Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …

Effective predictive biomarkers are needed to enable personalized medicine and increase
treatment efficacy and survival for cancer patients, thereby reducing toxic side effects and …

Organoid technologies enable the creation of in vitro physiologic systems that model tissues
of origin more accurately than classical culture approaches. Seminal characteristics of these …

Patient-derived organoids (PDO) are a new biomedical research model that can reconstruct
phenotypic and genetic characteristics of the original tissue and are useful for research on …

Image-based phenotypic screening relies on the extraction of multivariate information from
cells cultured under a large variety of conditions. Technical advances in high-throughput …

Combinatorial therapies that target multiple pathways have shown great promises for
treating complex diseases. DrugComb (https://drugcomb. org/) is a web-based portal for the …

Gastric cancer ranks as the fifth most common human malignancy and the third leading
cause of cancer related deaths. Depending on tumor stage, endoscopic or surgical resection …

Malignant tumors are one of the leading causes of death which impose an increasingly
heavy burden on all countries. Therefore, the establishment of research models that closely …

Peristalsis in the digestive tract is crucial to maintain physiological functions. It remains
challenging to mimic the peristaltic microenvironment in gastrointestinal organoid culture …

Crohn's disease (CD) is an inflammatory bowel disease (IBD) with repeated remissions and
relapses. As the disease progresses, fibrosis and narrowing of the intestine occur, leading to …