Antimicrobial peptides (AMPs): A promising class of antimicrobial compounds
M Erdem Büyükkiraz, Z Kesmen - Journal of applied …, 2022 - academic.oup.com
Antimicrobial peptides (AMPs) are compounds, which have inhibitory activity against
microorganisms. In the last decades, AMPs have become powerful alternative agents that …
microorganisms. In the last decades, AMPs have become powerful alternative agents that …
Computational modeling of realistic cell membranes
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications
Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit prominent useful properties
including environmental sensitivity, high reactivity toward amines and biothiols (including …
including environmental sensitivity, high reactivity toward amines and biothiols (including …
Membrane curvature at a glance
HT McMahon, E Boucrot - Journal of cell science, 2015 - journals.biologists.com
Membrane curvature is an important parameter in defining the morphology of cells,
organelles and local membrane subdomains. Transport intermediates have simpler shapes …
organelles and local membrane subdomains. Transport intermediates have simpler shapes …
A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope
S Lee, JW Carrasquillo Rodrı́guez, H Merta… - Journal of Cell …, 2023 - rupress.org
Lipid composition determines organelle identity; however, whether the lipid composition of
the inner nuclear membrane (INM) domain of the ER contributes to its identity is not known …
the inner nuclear membrane (INM) domain of the ER contributes to its identity is not known …
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
C Galvagnion, JWP Brown… - Proceedings of the …, 2016 - National Acad Sciences
Intracellular α-synuclein deposits, known as Lewy bodies, have been linked to a range of
neurodegenerative disorders, including Parkinson's disease. α-Synuclein binds to synthetic …
neurodegenerative disorders, including Parkinson's disease. α-Synuclein binds to synthetic …
Drugging membrane protein interactions
H Yin, AD Flynn - Annual review of biomedical engineering, 2016 - annualreviews.org
The majority of therapeutics target membrane proteins, accessible on the surface of cells, to
alter cellular signaling. Cells use membrane proteins to transduce signals into cells …
alter cellular signaling. Cells use membrane proteins to transduce signals into cells …
Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity
M de Jesus, AH Settle, D Vorselen, TK Gaetjens… - Science …, 2024 - science.org
Immune cells have intensely physical lifestyles characterized by structural plasticity and
force exertion. To investigate whether specific immune functions require stereotyped …
force exertion. To investigate whether specific immune functions require stereotyped …
Switchable solvatochromic probes for live‐cell super‐resolution imaging of plasma membrane organization
DI Danylchuk, S Moon, K Xu… - Angewandte …, 2019 - Wiley Online Library
Visualization of the nanoscale organization of cell membranes remains challenging
because of the lack of appropriate fluorescent probes. Herein, we introduce a new design …
because of the lack of appropriate fluorescent probes. Herein, we introduce a new design …
Sterol transfer, PI 4P consumption, and control of membrane lipid order by endogenous OSBP
The network of proteins that orchestrate the distribution of cholesterol among cellular
organelles is not fully characterized. We previously proposed that oxysterol‐binding protein …
organelles is not fully characterized. We previously proposed that oxysterol‐binding protein …