Antimicrobial peptides (AMPs): A promising class of antimicrobial compounds

M Erdem Büyükkiraz, Z Kesmen - Journal of applied …, 2022 - academic.oup.com
Antimicrobial peptides (AMPs) are compounds, which have inhibitory activity against
microorganisms. In the last decades, AMPs have become powerful alternative agents that …

Computational modeling of realistic cell membranes

SJ Marrink, V Corradi, PCT Souza, HI Ingolfsson… - Chemical …, 2019 - ACS Publications
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications

C Jiang, H Huang, X Kang, L Yang, Z Xi… - Chemical Society …, 2021 - pubs.rsc.org
Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit prominent useful properties
including environmental sensitivity, high reactivity toward amines and biothiols (including …

Membrane curvature at a glance

HT McMahon, E Boucrot - Journal of cell science, 2015 - journals.biologists.com
Membrane curvature is an important parameter in defining the morphology of cells,
organelles and local membrane subdomains. Transport intermediates have simpler shapes …

A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope

S Lee, JW Carrasquillo Rodrı́guez, H Merta… - Journal of Cell …, 2023 - rupress.org
Lipid composition determines organelle identity; however, whether the lipid composition of
the inner nuclear membrane (INM) domain of the ER contributes to its identity is not known …

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

C Galvagnion, JWP Brown… - Proceedings of the …, 2016 - National Acad Sciences
Intracellular α-synuclein deposits, known as Lewy bodies, have been linked to a range of
neurodegenerative disorders, including Parkinson's disease. α-Synuclein binds to synthetic …

Drugging membrane protein interactions

H Yin, AD Flynn - Annual review of biomedical engineering, 2016 - annualreviews.org
The majority of therapeutics target membrane proteins, accessible on the surface of cells, to
alter cellular signaling. Cells use membrane proteins to transduce signals into cells …

Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity

M de Jesus, AH Settle, D Vorselen, TK Gaetjens… - Science …, 2024 - science.org
Immune cells have intensely physical lifestyles characterized by structural plasticity and
force exertion. To investigate whether specific immune functions require stereotyped …

Switchable solvatochromic probes for live‐cell super‐resolution imaging of plasma membrane organization

DI Danylchuk, S Moon, K Xu… - Angewandte …, 2019 - Wiley Online Library
Visualization of the nanoscale organization of cell membranes remains challenging
because of the lack of appropriate fluorescent probes. Herein, we introduce a new design …

Sterol transfer, PI 4P consumption, and control of membrane lipid order by endogenous OSBP

B Mesmin, J Bigay, J Polidori, D Jamecna… - The EMBO …, 2017 - embopress.org
The network of proteins that orchestrate the distribution of cholesterol among cellular
organelles is not fully characterized. We previously proposed that oxysterol‐binding protein …