In recent years, sensory neuroscientists have made major efforts to dissect the structure and
function of ribbon synapses which process sensory information in the eye and ear. This …

Calcium influx through voltage-gated Ca (CaV) channels is the first step in synaptic
transmission. This review concerns CaV channels at ribbon synapses in primary sense …

Light-evoked voltage responses of rod and cone photoreceptor cells in the vertebrate retina
must be converted to a train of synaptic vesicle release events for transmission to …

Exocytosis is a Ca2+-regulated process that requires the participation of Ca2+ sensors. In
the 1980s, two classes of Ca2+-binding proteins were proposed as putative Ca2+ sensors …

Glutamate release from rod and cone photoreceptor cells involves presynaptic ribbons
composed largely of the protein RIBEYE. To examine roles of ribbons in rods and cones, we …

The cochlea processes auditory signals over a wide range of frequencies and intensities.
However, the transfer characteristics at hair cell ribbon synapses are still poorly understood …

Ribbon synapses reliably transmit synaptic signals over a broad signalling range. Rod
photoreceptor ribbon synapses are capable of transmitting signals generated by the …

The vertebrate visual system can detect and transmit signals from single photons. To
understand how single-photon responses are transmitted, we characterized voltage …

The sense of vision begins in the retina, where light is detected and processed through a
complex series of synaptic connections into meaningful information relayed to the brain via …

Brain-derived neurotrophic factor (BDNF) is an important regulator of circuit development,
neuronal survival, and plasticity throughout the nervous system. In the visual system, BDNF …