Plant flavonoids show anti-inflammatory activity in vitro and in vivo. Although not fully
understood, several action mechanisms are proposed to explain in vivo anti-inflammatory …

Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used to treat arthritis, menstrual
pain, and headache. Although they are effective, their long-term use is limited by …

The antiphospholipid syndrome is an autoimmune disorder of hypercoagulability
characterized by the presence of autoantibodies to various phospholipids or phospholipid …

Background Patients with arthritis and vascular disease may receive both low-dose aspirin
and other nonsteroidal antiinflammatory drugs. We therefore investigated potential …

A better understanding of the pathophysiology of rheumatoid arthritis, together with
influential trials aimed at treating early stages of the disease, has altered therapy. This article …

Dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act by
blocking the formation of both prostaglandins and leucotrienes but do not affect lipoxin …

Selective inhibitors of cyclooxygenase (COX)-2 afford relief from pain and inflammation.
They could also prove useful in the chemoprevention of cancer and are being investigated …

Pain Assessment and Pharmacologic Management, by highly renowned authors Chris
Pasero and Margo McCaffery, is destined to become the definitive resource in pain …

Objectives: To provide an overview on: 1) the expression of cyclooxygenase (COX)-2 in
articular tissues; 2) the role of prostaglandin E2 (PGE2) in these tissue functions; and 3) …

We investigated the mechanisms by which inhibitors of prostaglandin G/H synthase-2
(PGHS-2; known colloquially as COX-2) increase the incidence of myocardial infarction and …