International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB1 and CB2

RG Pertwee, AC Howlett, ME Abood… - Pharmacological …, 2010 - ASPET
There are at least two types of cannabinoid receptors (CB1 and CB2). Ligands activating
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9 …

CB2 receptor in microglia: the guardian of self-control

JA Komorowska-Müller, AC Schmöle - International journal of molecular …, 2020 - mdpi.com
Microglia are key to maintaining the homeostasis of the brain. These immune cells of the
brain can be our biggest ally in fighting infections, but can worsen pathology or hinder …

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9‐tetrahydrocannabinol, cannabidiol and Δ9‐tetrahydrocannabivarin

RG Pertwee - British journal of pharmacology, 2008 - Wiley Online Library
Cannabis sativa is the source of a unique set of compounds known collectively as plant
cannabinoids or phytocannabinoids. This review focuses on the manner with which three of …

CB2: a cannabinoid receptor with an identity crisis

BK Atwood, K Mackie - British journal of pharmacology, 2010 - Wiley Online Library
CB2 was first considered to be the 'peripheral cannabinoid receptor'. This title was bestowed
based on its abundant expression in the immune system and presumed absence from the …

Obesity: Current and potential pharmacotherapeutics and targets

V Narayanaswami, LP Dwoskin - Pharmacology & therapeutics, 2017 - Elsevier
Obesity is a global epidemic that contributes to a number of health complications including
cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders …

Cannabinoid receptor 2 signaling in neurodegenerative disorders: from pathogenesis to a promising therapeutic target

T Cassano, S Calcagnini, L Pace, F De Marco… - Frontiers in …, 2017 - frontiersin.org
As a consequence of an increasingly aging population, the number of people affected by
neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and …

Complex regional pain syndrome: a recent update

EL Goh, S Chidambaram, D Ma - Burns & trauma, 2017 - academic.oup.com
Complex regional pain syndrome (CRPS) is a debilitating condition affecting the limbs that
can be induced by surgery or trauma. This condition can complicate recovery and impair …

Emerging strategies for exploiting cannabinoid receptor agonists as medicines

RG Pertwee - British journal of pharmacology, 2009 - Wiley Online Library
Mandarin translation of abstract Medicines that activate cannabinoid CB1 and CB2 receptor
are already in the clinic. These are Cesamet®(nabilone), Marinol®(dronabinol; Δ9 …

An overview of the cannabinoid type 2 receptor system and its therapeutic potential

B Bie, J Wu, JF Foss, M Naguib - Current Opinion in …, 2018 - journals.lww.com
An overview of the cannabinoid type 2 receptor system and it... : Current Opinion in
Anesthesiology An overview of the cannabinoid type 2 receptor system and its therapeutic …

Cannabinoids and pain: sites and mechanisms of action

K Starowicz, DP Finn - Advances in Pharmacology, 2017 - Elsevier
The endocannabinoid system, consisting of the cannabinoid 1 receptor (CB 1 R) and
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …