An optimal antimicrobial dose provides enough drug to achieve a clinical response while
minimizing toxicity and development of drug resistance. There can be considerable …

OBJECTIVES: Beta-lactam antibiotics exhibit high interindividual variability in drug
concentrations in patients with critical illness which led to an interest in the use of …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Critically ill patients with sepsis or septic shock are at an increased risk of death. Early and
aggressive interventions are essential for improving clinical outcomes. There are a number …

Background In recent years, numerous dosing studies have been conducted to optimize
therapeutic antibiotic exposures in patients with serious infections. These studies have led to …

Antimicrobial resistance is an important global issue that impacts the efficacy of established
antimicrobial therapy. This is true globally and within the Arab countries of the Middle East …

Background Current guidelines and literature support the use of therapeutic drug monitoring
(TDM) to optimize β-lactam treatment in adult ICU patients. Objectives To describe the …

Optimization of antibiotic dosing is a treatment intervention that is likely to improve outcomes
in severe infections. The aim of this retrospective study was to describe the therapeutic …

The emergence of carbapenemase-producing Enterobacterales (CPE) as a major cause of
invasive infection both within the UK and internationally poses a very real concern for all …

Introduction Patients in intensive care units (ICU) are often developing severe infections in
which are associated with significant mortality rates. A number of novel technologies for the …