The known seven mammalian receptor subunits (P2X1–7) form cationic channels gated by
ATP. Three subunits compose a receptor channel. Each subunit is a polypeptide consisting …

The P2X7 receptor (P2X7R) possesses a unique structure associated to an as yet not fully
understood mechanism of action that facilitates cell permeability to large ionic molecules …

Only a subpopulation of non-small cell lung cancer (NSCLC) patients responds to
immunotherapies, highlighting the urgent need to develop therapeutic strategies to improve …

Olfactory dysfunction, one of the earliest non-motor symptoms of Parkinson disease (PD), is
accompanied by abnormal deposition of SNCA/α-synuclein in the olfactory bulb (OB). The …

Microglia, a type of innate immune cell of the brain, regulates neurogenesis, immunological
surveillance, redox imbalance, cognitive and behavioral changes under normal and …

The adenosine 5′-triphosphate-gated P2X4 receptor channel is a promising target in
neuroinflammatory disorders, but the ability to effectively target these receptors in models of …

Neurosteroids are steroids synthesized de novo in the brain from cholesterol in an
independent manner from peripheral steroid sources. The term “neuroactive steroid …

The family of ligand-gated ion channels known as P2X receptors were discovered several
decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research …

Ion channels have been characterized as promising drug targets for treatment of numerous
human diseases. Functions of ion channels can be fine-tuned by allosteric modulators …

Prostate cancer (PCa) is the most frequently diagnosed cancer in men, causing
considerable morbidity and mortality. The P2X4 receptor (P2X4R) is the most ubiquitously …