Synthetic product-based approach toward potential antileishmanial drug development
Leishmaniasis is a parasitic disease and is categorized as a tropically neglected disease
(NTD) with no effective vaccines available. The available chemotherapeutics against …
(NTD) with no effective vaccines available. The available chemotherapeutics against …
Metalloenzyme Inhibitors against Zoonotic Infections: Focus on Leishmania and Schistosoma
S Rossi, V Tudino, G Carullo, S Butini… - ACS Infectious …, 2024 - ACS Publications
The term “zoonosis” denotes diseases transmissible among vertebrate animals and
humans. These diseases constitute a significant public health challenge, comprising 61% of …
humans. These diseases constitute a significant public health challenge, comprising 61% of …
Synthesis and Biophysical and Biological Studies of N-Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites
JJ Nué-Martinez, D Cisneros… - Journal of Medicinal …, 2023 - ACS Publications
The AT-rich mitochondrial DNA (kDNA) of trypanosomatid parasites is a target of DNA minor
groove binders. We report the synthesis, antiprotozoal screening, and SAR studies of three …
groove binders. We report the synthesis, antiprotozoal screening, and SAR studies of three …
N-substituted-4-(pyridin-4-ylalkyl) piperazine-1-carboxamides and related compounds as Leishmania CYP51 and CYP5122A1 inhibitors
C La Rosa, P Sharma, MJ Dar, Y Jin, L Qin… - Bioorganic & Medicinal …, 2024 - Elsevier
CYP5122A1, an enzyme involved in sterol biosynthesis in Leishmania, was recently
characterized as a sterol C4-methyl oxidase. Screening of a library of compounds against …
characterized as a sterol C4-methyl oxidase. Screening of a library of compounds against …
A combined 2-D and 3-D QSAR modeling, molecular docking study, design, and pharmacokinetic profiling of some arylimidamide-azole hybrids as superior L …
Background Leishmaniasis is one of the neglected tropical diseases which is prevalent in
the tropical regions of the world most especially in Africa. It is caused by the Leishmania …
the tropical regions of the world most especially in Africa. It is caused by the Leishmania …
Arylimidamides for use in treatment of cancers
C07D233/54—Heterocyclic compounds containing 1, 3-diazole or hydrogenated 1, 3-
diazole rings, not condensed with other rings having two double bonds between ring …
diazole rings, not condensed with other rings having two double bonds between ring …
[HTML][HTML] CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles
Visceral leishmaniasis, caused by Leishmania donovani, is a life-threatening parasitic
disease, but current antileishmanial drugs are limited and have severe drawbacks. There …
disease, but current antileishmanial drugs are limited and have severe drawbacks. There …