How zebrafish can drive the future of genetic-based hearing and balance research
Over the last several decades, studies in humans and animal models have successfully
identified numerous molecules required for hearing and balance. Many of these studies …
identified numerous molecules required for hearing and balance. Many of these studies …
Detecting novel ototoxins and potentiation of ototoxicity by disease settings
Over 100 drugs and chemicals are associated with permanent hearing loss, tinnitus, and
vestibular deficits, collectively known as ototoxicity. The ototoxic potential of drugs is rarely …
vestibular deficits, collectively known as ototoxicity. The ototoxic potential of drugs is rarely …
Tiltable objective microscope visualizes selectivity for head motion direction and dynamics in zebrafish vestibular system
M Tanimoto, I Watakabe, S Higashijima - Nature communications, 2022 - nature.com
Spatio-temporal information about head orientation and movement is fundamental to the
sense of balance and motion. Hair cells (HCs) in otolith organs of the vestibular system …
sense of balance and motion. Hair cells (HCs) in otolith organs of the vestibular system …
Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins
A Ballesteros, C Fenollar-Ferrer, KJ Swartz - Elife, 2018 - elifesciences.org
The hair cell mechanotransduction (MET) channel complex is essential for hearing, yet it's
molecular identity and structure remain elusive. The transmembrane channel–like 1 (TMC1) …
molecular identity and structure remain elusive. The transmembrane channel–like 1 (TMC1) …
EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia
Hair cells detect sound, head position or water movements when their mechanosensory hair
bundle is deflected. Each hair bundle has an asymmetric architecture that restricts stimulus …
bundle is deflected. Each hair bundle has an asymmetric architecture that restricts stimulus …
Retrograde mitochondrial transport is essential for organelle distribution and health in zebrafish neurons
A Mandal, HTC Wong, K Pinter… - Journal of …, 2021 - Soc Neuroscience
In neurons, mitochondria are transported by molecular motors throughout the cell to form
and maintain functional neural connections. These organelles have many critical functions …
and maintain functional neural connections. These organelles have many critical functions …
Synaptic mitochondria regulate hair-cell synapse size and function
Sensory hair cells in the ear utilize specialized ribbon synapses. These synapses are
defined by electron-dense presynaptic structures called ribbons, composed primarily of the …
defined by electron-dense presynaptic structures called ribbons, composed primarily of the …
Lateral line ablation by ototoxic compounds results in distinct rheotaxis profiles in larval zebrafish
The zebrafish lateral line is an established model for hair cell organ damage, yet few studies
link mechanistic disruptions to changes in biologically relevant behavior. We used larval …
link mechanistic disruptions to changes in biologically relevant behavior. We used larval …
Distinct progenitor populations mediate regeneration in the zebrafish lateral line
Mechanosensory hair cells of the zebrafish lateral line regenerate rapidly following damage.
These renewed hair cells arise from the proliferation of surrounding support cells, which …
These renewed hair cells arise from the proliferation of surrounding support cells, which …
Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels
Calcium and integrin-binding protein 2 (CIB2) and CIB3 bind to transmembrane channel-like
1 (TMC1) and TMC2, the pore-forming subunits of the inner-ear mechano-electrical …
1 (TMC1) and TMC2, the pore-forming subunits of the inner-ear mechano-electrical …