Analysis of organic polymorphs. A review

TL Threlfall - Analyst, 1995 - pubs.rsc.org
Polymorphism1-7 in the chemical sense of the word* is a phenomenon of the solid state,
associated with the structure of the solid. It has proved difficult to define precisely although …

Thermal analysis and calorimetric methods in the characterisation of polymorphs and solvates

D Giron - Thermochimica acta, 1995 - Elsevier
The definitions and thermodynamic background for interpreting thermal analysis data are
presented in this review. Most drug substances and excipients which have been reported to …

[图书][B] Industrial applications of X-ray diffraction

F Smith - 1999 - books.google.com
By illustrating a wide range of specific applications in all major industries, this work
broadens the coverage of X-ray diffraction beyond basic tenets, research and academic …

NMR studies of organic polymorphs & solvates

RK Harris - Analyst, 2006 - pubs.rsc.org
This review article describes the applications of NMR to the study of polymorphs and related
forms (solvates) of organic (especially pharmaceutical) compounds, for which it is of …

Solid‐state NMR studies of pharmaceutical systems

M Geppi, G Mollica, S Borsacchi… - Applied Spectroscopy …, 2008 - Taylor & Francis
High‐and low‐resolution solid‐state nuclear magnetic resonance (SSNMR) applications to
the study of pharmaceuticals are reviewed. Examples are shown involving the use of mono …

Crystal chemistry and solvent effects in polymorphic systems Sulfathiazole

N Blagden, RJ Davey, HF Lieberman… - Journal of the …, 1998 - pubs.rsc.org
Sulfathiazole, a compound that forms four known crystal structures, has been examined with
a view to understanding its polymorphism. A graph set approach was used to classify the …

Design of controlled-release solid dosage forms of alginate and chitosan using microwave

TW Wong, LW Chan, SB Kho, PWS Heng - Journal of Controlled Release, 2002 - Elsevier
The influence of microwave irradiation on the drug release properties of alginate, alginate–
chitosan and chitosan beads was investigated. The beads were prepared with the highest …

Characterization of temperature-induced phase transitions in five polymorphic forms of sulfathiazole by terahertz pulsed spectroscopy and differential scanning …

JA Zeitler, DA Newnham, PF Taday, TL Threlfall… - Journal of …, 2006 - Elsevier
The far-infrared properties of all five known polymorphic forms of the drug sulfathiazole have
been studied by terahertz pulsed spectroscopy and low-frequency Raman spectroscopy …

Solubility increases associated with crystalline drug nanoparticles: methodologies and significance

B Van Eerdenbrugh, J Vermant, JA Martens… - Molecular …, 2010 - ACS Publications
In this manuscript, the determination of solubility of crystalline drug nanosuspensions by a
range of methods is critically investigated. As the determinations of solubility were performed …

Crystallization of polymorphs: the effect of solvent

S Khoshkhoo, J Anwar - Journal of Physics D: Applied Physics, 1993 - iopscience.iop.org
The effect of solvent in crystallization of polymorphs has been studied using the drug
sulphathiazole as a model compound. The solubilities of the four polymorphic forms of …