Role of viral infections in the pathogenesis of Sjögren's syndrome: Different characteristics of Epstein-Barr virus and HTLV-1

H Nakamura, T Shimizu, A Kawakami - Journal of Clinical Medicine, 2020 - mdpi.com
Viruses are possible pathogenic agents in several autoimmune diseases. Sjögren's
syndrome (SS), which involves exocrine dysfunction and the appearance of autoantibodies …

Epstein–Barr virus hijacks DNA damage response transducers to orchestrate its life cycle

PM Hau, SW Tsao - Viruses, 2017 - mdpi.com
The Epstein–Barr virus (EBV) is a ubiquitous virus that infects most of the human population.
EBV infection is associated with multiple human cancers, including Burkitt's lymphoma …

Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses

J Chen, Z Lu, W Gong, X Xiao, X Feng… - Proceedings of the …, 2022 - National Acad Sciences
Inhibition of host DNA damage response (DDR) is a common mechanism used by viruses to
manipulate host cellular machinery and orchestrate viral life cycles. Epstein-Barr virus …

Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells

X Li, EM Burton, S Bhaduri-McIntosh - PLoS pathogens, 2017 - journals.plos.org
Trials to reintroduce chloroquine into regions of Africa where P. falciparum has regained
susceptibility to chloroquine are underway. However, there are long-standing concerns …

p62/SQSTM1 promotes mitophagy and activates the NRF2-mediated antioxidant and anti-inflammatory response restraining EBV-driven B lymphocyte proliferation

MS Gilardini Montani, G Tarquini, R Santarelli… - …, 2022 - academic.oup.com
Reactive oxygen species (ROS) and DNA repair, respectively, promote and limit oncogenic
transformation of B cells driven by Epstein-Barr virus (EBV). We have previously shown that …

A screen for Epstein-Barr virus proteins that inhibit the DNA damage response reveals a novel histone binding protein

TH Ho, J Sitz, Q Shen, A Leblanc-Lacroix… - Journal of …, 2018 - Am Soc Microbiol
To replicate and persist in human cells, linear double-stranded DNA (dsDNA) viruses, such
as Epstein-Barr virus (EBV), must overcome the host DNA damage response (DDR) that is …

[HTML][HTML] Interplay between the DNA damage response and the life cycle of DNA tumor viruses

CJ Studstill, M Mac, CA Moody - Tumour Virus Research, 2023 - Elsevier
Approximately 20% of human cancers are associated with virus infection. DNA tumor viruses
can induce tumor formation in host cells by disrupting the cell's DNA replication and repair …

Niclosamide inhibits lytic replication of Epstein-Barr virus by disrupting mTOR activation

L Huang, M Yang, Y Yuan, X Li, E Kuang - Antiviral research, 2017 - Elsevier
Infection with the oncogenic γ-herpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-
associated herpesvirus (KSHV) cause several severe malignancies in humans. Inhibition of …

Epstein-Barr virus inactivates the transcriptome and disrupts the chromatin architecture of its host cell in the first phase of lytic reactivation

A Buschle, P Mrozek-Gorska… - Nucleic acids …, 2021 - academic.oup.com
Abstract Epstein-Barr virus (EBV), a herpes virus also termed HHV 4 and the first identified
human tumor virus, establishes a stable, long-term latent infection in human B cells, its …

Resveratrol inhibits Extranodal NK/T cell lymphoma through activation of DNA damage response pathway

X Sui, C Zhang, J Zhou, S Cao, C Xu, F Tang… - Journal of Experimental …, 2017 - Springer
Abstract Background Extranodal NK/T cell lymphoma (NKTCL) is a highly aggressive non-
Hodgkin lymphoma with poor prognosis. Resveratrol (RSV, 3, 5, 4′-trihydroxystilbene), a …