B cell responses against influenza viruses: short-lived humoral immunity against a life-long threat
Antibodies are critical for providing protection against influenza virus infections. However,
protective humoral immunity against influenza viruses is limited by the antigenic drift and …
protective humoral immunity against influenza viruses is limited by the antigenic drift and …
Generation of high quality memory B cells
T Inoue, R Shinnakasu, T Kurosaki - Frontiers in immunology, 2022 - frontiersin.org
Protection against pathogen re-infection is mediated, in large part, by two humoral cellular
compartments, namely, long-lived plasma cells and memory B cells. Recent data have …
compartments, namely, long-lived plasma cells and memory B cells. Recent data have …
Broadly neutralizing antibodies target a haemagglutinin anchor epitope
Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus
have the potential to provide near universal protection against influenza virus infection …
have the potential to provide near universal protection against influenza virus infection …
Parallelism of intestinal secretory IgA shapes functional microbial fitness
T Rollenske, S Burkhalter, L Muerner, S von Gunten… - Nature, 2021 - nature.com
Dimeric IgA secreted across mucous membranes in response to nonpathogenic taxa of the
microbiota accounts for most antibody production in mammals. Diverse binding specificities …
microbiota accounts for most antibody production in mammals. Diverse binding specificities …
[HTML][HTML] Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease
Pan-betacoronavirus neutralizing antibodies may hold the key to developing broadly
protective vaccines against novel pandemic coronaviruses and to more effectively respond …
protective vaccines against novel pandemic coronaviruses and to more effectively respond …
B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV
Monoclonal antibodies (mAbs) are a focus in vaccine and therapeutic design to counteract
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants. Here, we …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants. Here, we …
Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus
M Sangesland, AT de la Peña, S Boyoglu-Barnum… - Immunity, 2022 - cell.com
Human broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin stalk of group 1
influenza A viruses (IAVs) are biased for IGHV1-69 alleles that use phenylalanine (F54) but …
influenza A viruses (IAVs) are biased for IGHV1-69 alleles that use phenylalanine (F54) but …
The memory B cell response to influenza vaccination is impaired in older persons
AR Burton, SM Guillaume, WS Foster, AK Wheatley… - Cell reports, 2022 - cell.com
Influenza infection imparts an age-related increase in mortality and morbidity. The most
effective countermeasure is vaccination; however, vaccines offer modest protection in older …
effective countermeasure is vaccination; however, vaccines offer modest protection in older …
A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike
Delineating the origins and properties of antibodies elicited by SARS-CoV-2 infection and
vaccination is critical for understanding their benefits and potential shortcomings. Therefore …
vaccination is critical for understanding their benefits and potential shortcomings. Therefore …
Defining and studying B cell receptor and TCR interactions
CG Rappazzo, ML Fernández-Quintero… - The Journal of …, 2023 - journals.aai.org
Abstract BCRs (Abs) and TCRs (or adaptive immune receptors [AIRs]) are the means by
which the adaptive immune system recognizes foreign and self-antigens, playing an integral …
which the adaptive immune system recognizes foreign and self-antigens, playing an integral …