Cyclooxygenases (COXs) oxidize arachidonic acid to prostaglandin (PG) G 2 and H 2
followed by PG synthases that generates PGs and thromboxane (TX) A 2. COXs are divided …

Three enzyme systems, cyclooxygenases that generate prostaglandins, lipoxygenases that
form hydroxy derivatives and leukotrienes, and epoxygenases that give rise to …

A series of novel 4-Benzyl-1, 3-thiazole derivatives was synthesized by applying analogue-
based drug design approach and they were screened for anti-inflammatory activity …

The efficacy of nonsteroidal anti‐inflammatory drugs (NSAIDs) against inflammation, pain,
and fever has been supporting their worldwide use in the treatment of painful conditions and …

Inflammatory mechanisms are thought to contribute to lesion pathogenesis and neuronal
cell death in Alzheimer's disease. Transforming growth factor-β (TGF-β) plays a central role …

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders known.
Estimates from the Alzheimer's Association suggest that there are currently 5.8 million …

Inflammation is characteristic of a broad spectrum of neurodegenerative diseases. These
include Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases, amyotrophic lateral …

A key feature of prion diseases is the conversion of the normal, cellular prion protein (PrP C)
into β-sheet-rich disease-related isoforms (PrP Sc), the deposition of which is thought to lead …

Gas6, a product of the growth-arrest-specific gene 6, protects neurons from serum
deprivation-induced apoptosis. Neuronal apoptosis is also caused by amyloid β protein …

A series of novel acrylic acid derivatives bearing at the 3 position thienyl, furfuryl and 3, 5-
ditert-butyl-4-hydroxyphenyl substituents have been designed, synthesized and tested as …