Nuclear factor of κB (NF-κB) is a sequence-specific transcription factor that is known to be
involved in the inflammatory and innate immune responses. Although the importance of NF …

The cyclooxygenase (COX) enzymes catalyze a key step in the conversion of arachidonate
to PGH 2, the immediate substrate for a series of cell specific prostaglandin and …

Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H
2: constitutive COX-1 and inducible COX-2. To assess the role of COX-2 in colorectal …

Recent epidemiologic studies have shown a 40–50% reduction in mortality from colorectal
cancer in individuals who take nonsteroidal antiinflammatory drugs on a regular basis …

Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …

Mesenchymal cells in the intestine comprise a variety of cell types of diverse origins,
functions, and molecular markers. They provide mechanical and structural support and have …

Background and aims Chronic inflammation, induced by biological, chemical, and physical
factors, was associated with increased risk of human cancer at various sites. Chronic …

Cyclooxygenase (COX), a key enzyme in the prostanoid biosynthetic pathway, has received
considerable attention due to its role in human cancers. Observational and randomized …

Curcumin, a major yellow pigment and active component of turmeric, has been shown to
possess anti-inflammatory and anti-cancer activities. Cyclooxygenase (COX)-2 plays an …

Intestinal subepithelial myofibroblasts (ISEMF) and the interstitial cells of Cajal are the two
types of myofibroblasts identified in the intestine. Intestinal myofibroblasts are activated and …