Bodywide ecological interventions on cancer
Historically, cancer research and therapy have focused on malignant cells and their tumor
microenvironment. However, the vascular, lymphatic and nervous systems establish long …
microenvironment. However, the vascular, lymphatic and nervous systems establish long …
[HTML][HTML] Immunoregulation in cancer-associated cachexia
Background Cancer-associated cachexia is a multi-organ disorder associated with
progressive weight loss due to a variable combination of anorexia, systemic inflammation …
progressive weight loss due to a variable combination of anorexia, systemic inflammation …
ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis
O Motiño, F Lambertucci… - Proceedings of the …, 2022 - National Acad Sciences
Acyl-coenzyme A (CoA)–binding protein (ACBP), also known as diazepam-binding inhibitor
(DBI), is an extracellular feedback regulator of autophagy. Here, we report that injection of a …
(DBI), is an extracellular feedback regulator of autophagy. Here, we report that injection of a …
Acyl coenzyme A binding protein (ACBP): An aging‐and disease‐relevant “autophagy checkpoint”
Acyl coenzyme A binding protein (ACBP), also known as diazepam‐binding inhibitor (DBI),
is a phylogenetically ancient protein present in some eubacteria and the entire eukaryotic …
is a phylogenetically ancient protein present in some eubacteria and the entire eukaryotic …
High plasma concentrations of acyl‐coenzyme A binding protein (ACBP) predispose to cardiovascular disease: Evidence for a phylogenetically conserved proaging …
Autophagy defects accelerate aging, while stimulation of autophagy decelerates aging. Acyl‐
coenzyme A binding protein (ACBP), which is encoded by a diazepam‐binding inhibitor …
coenzyme A binding protein (ACBP), which is encoded by a diazepam‐binding inhibitor …
From benzodiazepines to fatty acids and beyond: revisiting the role of ACBP/DBI
Four decades ago Costa and colleagues identified a small, secreted polypeptide in the brain
that can displace the benzodiazepine diazepam from the GABA A receptor, and was thus …
that can displace the benzodiazepine diazepam from the GABA A receptor, and was thus …
A distinct Acyl-CoA binding protein (ACBP6) shapes tissue plasticity during nutrient adaptation in Drosophila
Nutrient availability is a major selective force in the evolution of metazoa, and thus plasticity
in tissue function and morphology is shaped by adaptive responses to nutrient changes …
in tissue function and morphology is shaped by adaptive responses to nutrient changes …
[HTML][HTML] GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity
Objective Dysfunctional, unhealthy expansion of white adipose tissue due to excess dietary
intake is a process at the root of obesity and Type 2 Diabetes development. The objective of …
intake is a process at the root of obesity and Type 2 Diabetes development. The objective of …
An obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABAA receptor
G Anagnostopoulos, O Motiño, S Li, V Carbonnier… - Cell death & …, 2022 - nature.com
Acyl-coenzyme-A-binding protein (ACBP), also known as a diazepam-binding inhibitor
(DBI), is a potent stimulator of appetite and lipogenesis. Bioinformatic analyses combined …
(DBI), is a potent stimulator of appetite and lipogenesis. Bioinformatic analyses combined …
Inhibition of acyl-CoA binding protein (ACBP) by means of a GABAARγ2-derived peptide
G Anagnostopoulos, E Saavedra, F Lambertucci… - Cell Death & …, 2024 - nature.com
Acyl-CoA binding protein (ACBP) encoded by diazepam binding inhibitor (DBI) is an
extracellular inhibitor of autophagy acting on the gamma-aminobutyric acid A receptor …
extracellular inhibitor of autophagy acting on the gamma-aminobutyric acid A receptor …