Biological soft matter: intrinsically disordered proteins in liquid–liquid phase separation and biomolecular condensates

AV Fonin, IA Antifeeva, IM Kuznetsova… - Essays in …, 2022 - portlandpress.com
The facts that many proteins with crucial biological functions do not have unique structures
and that many biological processes are compartmentalized into the liquid-like biomolecular …

Aberrant liquid-liquid phase separation and amyloid aggregation of proteins related to neurodegenerative diseases

A Ahmad, VN Uversky, RH Khan - International Journal of Biological …, 2022 - Elsevier
Recent evidence has shown that the processes of liquid-liquid phase separation (LLPS) or
liquid-liquid phase transitions (LLPTs) are a crucial and prevalent phenomenon that …

[HTML][HTML] Liaisons dangereuses: Intrinsic Disorder in Cellular Proteins Recruited to Viral Infection-Related Biocondensates

G Bianchi, S Brocca, S Longhi, VN Uversky - International Journal of …, 2023 - mdpi.com
Liquid–liquid phase separation (LLPS) is responsible for the formation of so-called
membrane-less organelles (MLOs) that are essential for the spatio-temporal organization of …

[HTML][HTML] Biological Liquid–Liquid Phase Separation, Biomolecular Condensates, and Membraneless Organelles: Now You See Me, Now You Don't

VN Uversky - International Journal of Molecular Sciences, 2023 - mdpi.com
Liquid–liquid phase separation (LLPS, also known as biomolecular condensation) and the
related biogenesis of various membraneless organelles (MLOs) and biomolecular …

Phase separation of multicomponent peptide mixtures into dehydrated clusters with hydrophilic cores

WH Brown, DA Potoyan - Biophysical Journal, 2024 - cell.com
Phase separation of biomolecules underlies the formation and regulation of various
membraneless condensates in cells. How condensates function reliably while surrounded …

dSCOPE: a software to detect sequences critical for liquid–liquid phase separation

K Yu, Z Liu, H Cheng, S Li, Q Zhang, J Liu… - Briefings in …, 2023 - academic.oup.com
Membrane-based cells are the fundamental structural and functional units of organisms,
while evidences demonstrate that liquid–liquid phase separation (LLPS) is associated with …

[HTML][HTML] Effects of Mass Change on Liquid–Liquid Phase Separation of the RNA-Binding Protein Fused in Sarcoma

W Dong, C Tang, WT Chu, E Wang, J Wang - Biomolecules, 2023 - mdpi.com
In recent years, many experimental and theoretical studies of protein liquid–liquid phase
separation (LLPS) have shown its important role in the processes of physiology and …