Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …

As a public health emergency of international concern, the highly contagious coronavirus
disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of …

Gastrointestinal cancer (GIC), including gastric cancer and colorectal cancer, is a common
malignant tumor originating from the gastrointestinal epithelium. Although the pathogenesis …

Cancer represents the second most deadly disease and one of the most important public
health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy …

Anaplastic thyroid cancer (ATC) is an aggressive and lethal malignancy having a dismal
prognosis. Phytochemicals are bioactive components obtained from plants that have been …

Deguelin is a natural flavonoid extracted from plants belonging to the Lonchocarpus, Derris,
or Tephrosia genera. It inhibits AKT activity in tumors and has the potential to be used as a …

The overexpression of cyclin D1 and cyclin E due to their oncogenic potential and
amplification has been associated with a higher mortality rate in many cancers. The …

Pancreatic cancer is the third leading cause of cancer‐related deaths in the United States,
owing to its aggressive nature and suboptimal treatment options, emphasizing the need for …

The zebrafish is considered one of the most versatile experimental animal models. The
transparency of the embryos, the small size, the rapid development and the homology with …

Deguelin is a rotenoid of the flavonoid family, which can be extracted from Lonchocarpus,
Derris, or Tephrosia. It possesses the inhibition of cancer cell proliferation by inducing …