Death receptors are members of the tumor necrosis factor receptor superfamily
characterized by a cytoplasmic region known as the “death domain” that enables the …

Lipid membranes can spontaneously organize their components into domains of different
sizes and properties. The organization of membrane lipids into nanodomains might …

Glycosphingolipids (GSLs) exhibit a variety of functions in cellular differentiation and
interaction. Also, they are known to play a role as receptors in pathogen invasion. A less well …

The cell cortex serves as a critical nexus between the extracellular environment/cell
membrane and the underlying cytoskeleton and cytoplasm. In many cells, the cell cortex is …

Disruption of epithelial polarity is a key event in the acquisition of neoplastic growth. JNK
signalling is known to play an important part in driving the malignant progression of many …

Like all other monomeric or multimeric transmembrane proteins, receptors for
neurotransmitters are surrounded by a shell of lipids which form an interfacial boundary …

Brain cholesterol plays a critical role in Alzheimer's disease and other neurodegenerative
diseases. The molecular mechanisms linking cholesterol to neurotoxicity have remained …

Alzheimer, Parkinson and other neurodegenerative diseases involve a series of brain
proteins, referred to as 'amyloidogenic proteins', with exceptional conformational plasticity …

Signaling through classical death receptor Fas was mainly appreciated as a pro-death
pathway until recent reports characterized pro-inflammatory outcomes of Fas-mediated …

CD 95 (also known as Fas) is a member of the tumor necrosis factor receptor (TNFR)
superfamily. Its cognate ligand, CD 95L, is implicated in immune homeostasis and immune …