Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of the,
probably, most economically important disease for the pig industry worldwide. This disease …

The thymus is a vital organ of the immune system that plays an essential role in thymocyte
development and maturation. Thymic atrophy occurs with age (physiological thymic atrophy) …

Innate immunity is the front line for antiviral immune responses and bridges adaptive
immunity against viral infections. However, various viruses have evolved many strategies to …

Porcine reproductive and respiratory syndrome virus (PRRSV), an RNA virus widely
prevalent in pigs, results in significant economic losses worldwide. PRRSV can escape from …

Introduction Porcine reproductive and respiratory syndrome virus (PRRSV) emerged about
30 years ago and continues to cause major economic losses in the pork industry. The lack of …

Porcine reproductive and respiratory syndrome virus (PRRSV) induces a dysregulation on
the innate and adaptive immune responses. T-cell activation requires a proper interaction …

Transcription factors (TFs) modulate genes involved in cell-type-specific proliferative and
migratory properties, metabolic features, and effector functions. Porcine reproductive and …

PRRSV is capable of evading the effective immune response, thus persisting in piglets and
throughout the swine herd. We show here that PRRSV invades the thymus and causes …

Virulent porcine reproductive and respiratory syndrome virus (PRRSV) strains, such as the
Lena strain, have demonstrated a higher thymus tropism than low virulent strains. Virulent …

PRRSV-1 virulent strains cause high fever, marked respiratory disease and severe lesions
in lung and lymphoid organs. Regulated cell death (RCD), such as apoptosis, necroptosis …