Allostery is the most direct and efficient way for regulation of biological macromolecule
function, ranging from the control of metabolic mechanisms to signal transduction pathways …

Fragment-based drug discovery (FBDD) concerns the screening of low-molecular weight
compounds against macromolecular targets of clinical relevance. These compounds act as …

A wide range of methods are currently available for determining the dissociation constant
between a protein and interacting small molecules. However, most of these require access …

Fragment screening is widely used to identify attractive starting points for drug design.
However, its potential and limitations to assess the tractability of often challenging protein …

Fragment-based lead discovery (FBLD) has become a pillar in drug development. Typical
applications of this method comprise at least two biophysical screens as prefilter and a …

During meiosis, crossovers (COs) are typically required to ensure faithful chromosomal
segregation. Despite the requirement for at least one CO between each pair of …

Fragment-based drug discovery (FBDD) is contingent on the development of analytical
methods to identify weak protein–fragment noncovalent interactions. Herein we have …

In early-stage drug discovery, the hit-to-lead optimization (or “hit expansion”) stage entails
starting from a newly identified active compound and improving its potency or other …

A key question in mapping dynamics of protein-ligand interactions is to distinguish changes
at binding sites from those associated with long range conformational changes upon binding …

High Throughput Screening (HTS) is a successful strategy for finding hits and leads that
have the opportunity to be converted into drugs. In this paper we highlight novel …