The high mobility group protein 2 (HMGA2) regulates gene expression by binding to AT-rich
regions of DNA. Akin to other DNA architectural proteins, HMGA2 is highly expressed in …

Gastric cancer remains one of the most common cancers worldwide and one of the leading
cause for cancer-related deaths. Gastric adenocarcinoma is a multifactorial disease that is …

Pancreatic ductal adenocarcinoma (PDA) is a major cause of cancer-related death, with
limited therapeutic options available. This highlights the need for improved understanding of …

To understand the role of the extensive senescence-associated 3D genome reorganization,
we generated genome-wide chromatin interaction maps, epigenome, replication-timing …

Lung cancer is the leading cause of cancer-related deaths worldwide. The initiation and
progression of lung cancer is the result of the interaction between permanent genetic and …

Collagen is the most abundant protein in animals. Interactions between tumor cells and
collagen influence every step of tumor development. Type I collagen is the main fibrillar …

High-Mobility Group (HMG) chromosomal proteins are the most numerous nuclear non-
histone proteins. HMGB domain proteins are the most abundant and well-studied HMG …

High mobility group A 2 (HMGA2) is a protein that modulates the structure of chromatin in the
nucleus. Importantly, aberrant expression of HMGA2 occurs during carcinogenesis, and this …

High Mobility Group Box (HMGB) proteins are small architectural DNA binding proteins that
regulate multiple genomic processes such as DNA damage repair, nucleosome sliding …

HMGA (high mobility group A)(HMGA1 and HMGA2) are small non-histone proteins that can
bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors …