In response to various types of environmental and cellular stress, microglia rapidly activate
and exhibit either pro-or anti-inflammatory phenotypes to maintain tissue homeostasis …

Perfluorooctanesulfonic acid (PFOS), a fluorine-containing organic compound, can be
widely detected in the environment and living organisms. Accumulating evidence has shown …

Mitochondria are highly dynamic organelles whose fragmentation by fission is critical to their
functional integrity and cellular homeostasis. Here, we develop a method via optogenetic …

Deoxynivalenol (DON) is one of the most plentiful trichothecenes occurring in food and feed,
which brings severe health hazards to both animals and humans. This study aims to …

Noonan syndrome (NS) and related Noonan syndrome with multiple lentigines (NSML)
contribute to the pathogenesis of human diseases in the RASopathy family. This family of …

Sarcopenia is known as age-related muscle atrophy, which influences over a quarter of the
elderly population worldwide. It is characterized by a progressive decline in muscle mass …

Cellular organelles play fundamental roles in almost all cell behaviors. Mitochondria have
been reported to be functionally linked to various biological processes, including …

Copper (Cu) is one of the ubiquitous environmental pollutants which have raised wide
concerns about the potential toxic effects and public health threat. For deeply investigating …

SOS1 ablation causes specific defective phenotypes in MEFs including increased levels of
intracellular ROS. We showed that the mitochondria-targeted antioxidant MitoTEMPO …

Perfluorooctane sulfonate (PFOS), a synthetic chemical used in various commercial
applications and industrial settings, has led to contamination of drinking water and has been …