Abstract The NF-κB (Nuclear Factor kappa B) transcription factor plays crucial roles in the
regulation of numerous biological processes including development of the immune system …

NF-κB (nuclear factor kappa B) family transcription factors are master regulators of immune
and inflammatory processes in response to both injury and infection. In the latent state, NF …

The IκB kinase (IKK) complex is the signal integration hub for NF‐κB activation. Composed
of two serine‐threonine kinases (IKK α and IKK β) and the regulatory subunit NEMO (also …

Widespread adoption of mirror-image biological systems presents difficulties in accessing
the requisite D-protein substrates. In particular, mirror-image phage display has the potential …

The IKK kinase complex is the core element of the NF-κB cascade. It is essentially made of
two kinases (IKKα and IKKβ) and a regulatory subunit, NEMO/IKKγ. Additional components …

Activation of nuclear factor-κB (NF-κB), a key mediator of inducible transcription in immunity,
requires binding of NF-κB essential modulator (NEMO) to ubiquitinated substrates. Here, we …

The inhibitor of nuclear factor‐κB (IκB) kinase (IKK) complex is the master regulator of the NF‐
κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly …

The signaling module that specifies nuclear factor‐κΒ (NF‐κB) activation is a three‐
component system: NF‐κB, inhibitor of NF‐κΒ (IκΒ), and IκΒ kinase complex (IKK). IKK …

Tank-binding kinase I (TBK1) plays a key role in the innate immune system by integrating
signals from pattern-recognition receptors. Here, we report the X-ray crystal structures of …

A large body of literature describes elaborate NF-κB signaling networks induced by
inflammatory and immune signals. Decades of research has revealed that transcriptionally …