Matrix metalloproteinases shape the tumor microenvironment in cancer progression
S Niland, AX Riscanevo, JA Eble - International journal of molecular …, 2021 - mdpi.com
Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …
Immune dysregulation as a driver of idiopathic pulmonary fibrosis
K Shenderov, SL Collins, JD Powell… - The Journal of clinical …, 2021 - Am Soc Clin Investig
Idiopathic pulmonary fibrosis (IPF) affects hundreds of thousands of people worldwide,
reducing their quality of life and leading to death from respiratory failure within years of …
reducing their quality of life and leading to death from respiratory failure within years of …
Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease
B Vijayakumar, K Boustani, PP Ogger, A Papadaki… - Immunity, 2022 - cell.com
Some patients hospitalized with acute COVID-19 suffer respiratory symptoms that persist for
many months. We delineated the immune-proteomic landscape in the airways and …
many months. We delineated the immune-proteomic landscape in the airways and …
The extracellular matrix as a multitasking player in disease
Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …
Targeting metabolic dysregulation for fibrosis therapy
Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …
SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis
Background Severe acute respiratory syndrome (SARS)-CoV-2-induced coronavirus
disease-2019 (COVID-19) is a pandemic disease that affects> 2.8 million people worldwide …
disease-2019 (COVID-19) is a pandemic disease that affects> 2.8 million people worldwide …
Resolution of organ fibrosis
Fibrosis is the excessive accumulation of extracellular matrix that often occurs as a wound
healing response to repeated or chronic tissue injury, and may lead to the disruption of …
healing response to repeated or chronic tissue injury, and may lead to the disruption of …
Extracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics
MS Islam, A Ciavattini, F Petraglia… - Human reproduction …, 2018 - academic.oup.com
BACKGROUND Uterine leiomyoma (also known as fibroid or myoma) is the most common
benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can …
benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can …
A persistent neutrophil-associated immune signature characterizes post–COVID-19 pulmonary sequelae
Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have
recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
The leading role of epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and devastating interstitial
lung disease of unknown etiology, where the normal lung architecture is lost and replaced …
lung disease of unknown etiology, where the normal lung architecture is lost and replaced …