Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …

Summary Alpha-1 antitrypsin deficiency (AATD) arises from mutations in the SERPINA1
gene encoding alpha-1 antitrypsin (AAT) that lead to AAT retention in the endoplasmic …

Understanding Covid‐19 pathophysiology is crucial for a better understanding of the
disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a …

One would assume that the anti-inflammatory activity of α1-anti-trypsin (AAT) is the result of
inhibiting neutrophil enzymes. However, AAT exhibits tolerogenic activities that are difficult …

Islet cell transplantation has limited effectiveness because of an instant blood-mediated
inflammatory reaction (IBMIR) that occurs immediately after cell infusion and leads to …

Background Inflammation and coagulation are key processes in cardiovascular diseases
(CVDs). The Canakinumab Anti-inflammatory Thrombosis Outcome Study trial affirmed the …

As a newly emerging organ transplantation technique, islet transplantation has shown the
advantages of minimal trauma and high safety since it was first carried out. The proposal of …

Type 1 diabetes (T1D) is a metabolic disease characterized by hyperglycemia and can affect
multiple organs, leading to life-threatening complications. Increased prevalence of …

Primary graft dysfunction (PGD) is one of the most common complications in the early
postoperative period and is the most common cause of death in the first postoperative …

Background Detection of cholangiocarcinoma (CCA) remains a diagnostic challenge. We
established diagnostic peptide biomarkers in bile and urine based on capillary …