Recent advance on PTP1B inhibitors and their biomedical applications
Abstract Protein Tyrosine Phosphatase 1B (PTP1B), as one of the most important members
in PTP superfamily, plays a vital role in conducting various cellular functions. So far, PTP1B …
in PTP superfamily, plays a vital role in conducting various cellular functions. So far, PTP1B …
[HTML][HTML] Exploring protein tyrosine phosphatases (PTP) and PTP-1B inhibitors in management of diabetes mellitus
Type 2 diabetes mellitus (T2D) is a metabolic disorder that knows no boundaries and is
spread across the globe. It is one of the most widely spread metabolic disorder, which has …
spread across the globe. It is one of the most widely spread metabolic disorder, which has …
[HTML][HTML] An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering
Allostery is an inherent feature of proteins, but it remains challenging to reveal the
mechanisms by which allosteric signals propagate. A clearer understanding of this intrinsic …
mechanisms by which allosteric signals propagate. A clearer understanding of this intrinsic …
[HTML][HTML] Fludarabine, a potential DNA-dependent RNA polymerase inhibitor, as a prospective drug against monkeypox virus: A computational approach
HN Altayb - Pharmaceuticals, 2022 - mdpi.com
Monkeypox is a zoonotic contagious disease that has recently re-emerged in different
countries worldwide. Due to the lack of an effective treatment that eliminates the virus, there …
countries worldwide. Due to the lack of an effective treatment that eliminates the virus, there …
Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2
JR LaRochelle, M Fodor, JM Ellegast, X Liu… - Bioorganic & medicinal …, 2017 - Elsevier
The PTPN11 oncogene encodes the cytoplasmic protein tyrosine phosphatase SHP2,
which, through its role in multiple signaling pathways, promotes the progression of …
which, through its role in multiple signaling pathways, promotes the progression of …
Wang resin catalysed sonochemical synthesis of pyrazolo [4, 3-d] pyrimidinones and 2, 3-dihydroquinazolin-4 (1H)-ones: Identification of chorismate mutase inhibitors …
The enzyme chorismate mutase (or CM that is vital for the survival of bacteria) is an
interesting pharmacological target for the identification of new anti-tubercular agents. The 5 …
interesting pharmacological target for the identification of new anti-tubercular agents. The 5 …
[HTML][HTML] In silico screening of available drugs targeting non-small cell lung cancer targets: A drug repurposing approach
The RAS–RAF–MEK–ERK pathway plays a key role in malevolent cell progression in many
tumors. The high structural complexity in the upstream kinases limits the treatment progress …
tumors. The high structural complexity in the upstream kinases limits the treatment progress …
[HTML][HTML] MptpB promotes mycobacteria survival by inhibiting the expression of inflammatory mediators and cell apoptosis in macrophages
L Fan, X Wu, C Jin, F Li, S Xiong… - Frontiers in Cellular and …, 2018 - frontiersin.org
Tuberculosis is a severe contagious disease caused by Mycobacterium tuberculosis (Mtb).
To develop new vaccines and medicine against TB, there is an urgent need to provide …
To develop new vaccines and medicine against TB, there is an urgent need to provide …
Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B
A Mascarello, ACO Menegatti, A Calcaterra… - European journal of …, 2018 - Elsevier
Mycobacterium tuberculosis (Mtb) protein tyrosine phosphatases A and B (PtpA and PtpB)
have been recognized as potential molecular targets for the development of new therapeutic …
have been recognized as potential molecular targets for the development of new therapeutic …
[HTML][HTML] PTPσ inhibitors promote hematopoietic stem cell regeneration
Receptor type protein tyrosine phosphatase-sigma (PTPσ) is primarily expressed by adult
neurons and regulates neural regeneration. We recently discovered that PTPσ is also …
neurons and regulates neural regeneration. We recently discovered that PTPσ is also …