Metallodrugs offer potential for unique mechanism of drug action based on the choice of the
metal, its oxidation state, the types and number of coordinated ligands and the coordination …

Much success has been achieved with platinum-based chemotherapeutic agents, ie through
interactions with DNA. The long-term application of Pt complexes is thwarted by issues …

In the next two decades, the world is expected to see around 20 million cases of cancer.
Moreover, the types of cancer will vary considerably from country to other. Therefore, all …

Highlights•TNBC is an unmet medical need with poor survival rates and no targeted
therapy.•TNBC resists conventional chemotherapy and surgical strategies.•A review of 121 …

This article provides a comprehensive review of palladium compounds that have been
evaluated for anticancer activity in vivo or in vitro from the era of discovery of cisplatin up to …

Summary Chemical-, pharmacological-, and clinical-research on anticancer coordination
complexes has yielded remarkable anticancer agents such as cisplatin, carboplatin, and …

Since the introduction of cisplatin to oncology in 1978, Pt (II) and Pd (II) compounds have
been intensively studied with a view to develop the improved anticancer agents. Polynuclear …

Ethidium bromide was used to study perturbations induced in salmon sperm DNA
complexed with a series of platinum and palladium compounds obtained from chloro and …

A new approach to the synthesis of novel bifunctional dinuclear platinum complexes with
linear coordinating spermidine and spermine is reported. The synthetic pathway involves …

Schiff base metal complexes are of great importance in pharmaceutical science owing to
their unique chemical properties, which enable them to exhibit diverse biological activities …