A number of chronic metabolic pathologies, including obesity, diabetes, cardiovascular
disease, asthma, and cancer, cluster together to present the greatest threat to human health …

Intracellular Ca2+ signalling is a major signal transductional pathway in non-excitable cells,
responsible for the regulation of a variety of physiological functions. In the secretory …

While most of the efforts to uncover mechanisms contributing to bipolar disorder (BD)
focused on phenotypes at the mature neuron stage, little research has considered events …

The gut microbiome participates in numerous physiologic functions and communicates
intimately with the host immune system. Antimicrobial peptides are critical components of …

The endoplasmic reticulum (ER) plays a pivotal role in maintaining cellular homeostasis.
However, numerous environmental and genetic factors give rise to ER stress by inducing an …

Ca2+ entry into the cell via store-operated Ca2+ release-activated Ca2+ (CRAC) channels
triggers diverse signaling cascades that affect cellular processes like cell growth, gene …

Antiapoptotic Bcl-2-family members are well known for their 'mitochondrial'functions as
critical neutralizers of proapoptotic Bcl-2-family members, including the executioner …

The family of stromal interaction molecules (STIM) includes two widely expressed single‐
pass endoplasmic reticulum (ER) transmembrane proteins and additional splice variants …

STIM1 (stromal interaction molecule 1) and Orai proteins are the essential components of
Ca2+ release–activated Ca2+ (CRAC) channels. We focused on the role of cholesterol in …

Simple Summary Cell fate is ultimately determined by the precisely coordinated action of the
Ca2+-signaling machinery. During carcinogenesis, Ca2+ signaling is significantly …